======= CHMP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP6
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79643|79643]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FZ7|Q96FZ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610901|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT complex assembly|
|ESCRT III complex assembly|
|ESCRT III complex|
|negative regulation of epidermal growth factor-activated receptor activity|
|midbody abscission|
|regulation of exosomal secretion|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|viral budding|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|multivesicular body assembly|
|multivesicular body organization|
|cytokinetic process|
|virion assembly|
|negative regulation of epidermal growth factor receptor signaling pathway|
|mitotic metaphase plate congression|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|metaphase plate congression|
|negative regulation of signaling receptor activity|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|protein N-terminus binding|
|mitotic sister chromatid segregation|
|late endosome membrane|
|nucleus organization|
|sister chromatid segregation|
|vacuolar transport|
|mitotic nuclear division|
|macroautophagy|
|regulation of signaling receptor activity|
|viral life cycle|
|endosome membrane|
|nuclear chromosome segregation|
|regulation of exocytosis|
|negative regulation of protein kinase activity|
|endosomal transport|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|autophagy|
|process utilizing autophagic mechanism|
|protein-containing complex binding|
|chromosome segregation|
|negative regulation of transferase activity|
|nuclear division|
|vesicle organization|
|organelle fission|
|establishment of organelle localization|
|regulation of protein catabolic process|
|negative regulation of protein phosphorylation|
|endomembrane system organization|
|negative regulation of phosphorylation|
|cell division|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|viral process|
|regulation of secretion by cell|
|organelle assembly|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|regulation of kinase activity|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.27|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.24|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.23|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.16|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.16|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.15|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.12|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.1|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.06|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.02|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.02|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.92|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.87|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.81|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.78|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.78|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.75|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.71|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP6 Expression in NALM6 Cells: 3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>