======= CHP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHP1
  * **<color #00a2e8>Official Name</color>**: calcineurin like EF-hand protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11261|11261]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99653|Q99653]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606988|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate- phosphorylations in a calcium-dependent manner. {ECO:0000269|PubMed:10593895, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of sodium:proton antiporter activity|
|regulation of sodium:proton antiporter activity|
|positive regulation of protein glycosylation|
|cellular response to acidic pH|
|negative regulation of protein import into nucleus|
|negative regulation of protein import|
|negative regulation of protein autophosphorylation|
|negative regulation of calcineurin-mediated signaling|
|regulation of protein glycosylation|
|negative regulation of calcineurin-NFAT signaling cascade|
|positive regulation of sodium ion transmembrane transporter activity|
|hyaluronan catabolic process|
|positive regulation of glycoprotein biosynthetic process|
|negative regulation of nucleocytoplasmic transport|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of glycoprotein metabolic process|
|regulation of proton transport|
|cellular response to pH|
|response to acidic pH|
|protein kinase inhibitor activity|
|negative regulation of protein localization to nucleus|
|negative regulation of calcium-mediated signaling|
|positive regulation of protein targeting to membrane|
|hyaluronan metabolic process|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of sodium ion transport|
|regulation of protein targeting to membrane|
|potassium channel regulator activity|
|response to pH|
|regulation of glycoprotein biosynthetic process|
|calcium-ion regulated exocytosis|
|negative regulation of intracellular protein transport|
|regulation of glycoprotein metabolic process|
|regulation of protein autophosphorylation|
|regulation of sodium ion transmembrane transporter activity|
|cytoplasmic microtubule organization|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of intracellular transport|
|glycosaminoglycan catabolic process|
|calcium-dependent protein binding|
|regulation of sodium ion transmembrane transport|
|aminoglycan catabolic process|
|negative regulation of protein ubiquitination|
|endoplasmic reticulum-Golgi intermediate compartment|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of protein targeting|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular pH|
|regulation of sodium ion transport|
|regulation of cellular pH|
|microtubule bundle formation|
|transport vesicle|
|kinase binding|
|regulation of calcium-mediated signaling|
|regulation of pH|
|positive regulation of ion transmembrane transporter activity|
|negative regulation of phosphatase activity|
|regulation of nucleocytoplasmic transport|
|mucopolysaccharide metabolic process|
|cellular monovalent inorganic cation homeostasis|
|positive regulation of transporter activity|
|negative regulation of dephosphorylation|
|negative regulation of cellular protein localization|
|regulation of protein localization to nucleus|
|positive regulation of protein localization to membrane|
|membrane fusion|
|monovalent inorganic cation homeostasis|
|positive regulation of cation transmembrane transport|
|protein export from nucleus|
|microtubule cytoskeleton|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|glycosaminoglycan metabolic process|
|nuclear export|
|negative regulation of DNA-binding transcription factor activity|
|aminoglycan metabolic process|
|potassium ion transport|
|regulation of phosphatase activity|
|protein stabilization|
|membrane docking|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|regulation of dephosphorylation|
|negative regulation of protein kinase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|microtubule binding|
|negative regulation of kinase activity|
|regulation of ion transmembrane transporter activity|
|nucleocytoplasmic transport|
|regulation of transmembrane transporter activity|
|nuclear transport|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|regulation of transporter activity|
|regulation of protein stability|
|regulation of neuron death|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|regulation of intracellular transport|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|negative regulation of protein phosphorylation|
|focal adhesion|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|small molecule catabolic process|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|Golgi membrane|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|microtubule-based process|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|ion homeostasis|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|cation transport|
|membrane organization|
|regulation of kinase activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|regulation of transferase activity|
|positive regulation of transport|
|intracellular protein transport|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|secretion|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.06|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.01|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.98|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.83|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.82|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.84|
|[[:results:exp539|42°C R08 exp539]]|1.89|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.89|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.98|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.68|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.25|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.8|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|5.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:agpat6|AGPAT6]]|0.596|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHP1 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>