======= CHRNB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNB2
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic beta 2 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1141|1141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17787|P17787]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118507|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. {ECO:0000269|PubMed:22361591}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan LBD|
|Neur chan memb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lateral geniculate nucleus development|
|synaptic transmission involved in micturition|
|regulation of circadian sleep/wake cycle, REM sleep|
|conditioned taste aversion|
|positive regulation of dopamine secretion|
|optic nerve morphogenesis|
|positive regulation of synaptic transmission, dopaminergic|
|behavioral response to nicotine|
|micturition|
|negative regulation of action potential|
|regulation of circadian sleep/wake cycle, non-REM sleep|
|vestibulocochlear nerve development|
|cholinergic synapse|
|positive regulation of catecholamine secretion|
|ligand-gated ion channel activity|
|thalamus development|
|optic nerve development|
|dopaminergic synapse|
|regulation of synaptic transmission, dopaminergic|
|acetylcholine receptor activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine binding|
|regulation of circadian sleep/wake cycle, sleep|
|acetylcholine-gated channel complex|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|regulation of circadian sleep/wake cycle|
|central nervous system projection neuron axonogenesis|
|synaptic transmission, cholinergic|
|integral component of postsynaptic specialization membrane|
|cranial nerve morphogenesis|
|plasma membrane raft|
|acetylcholine receptor signaling pathway|
|positive regulation of response to drug|
|cellular response to acetylcholine|
|response to acetylcholine|
|neuromuscular synaptic transmission|
|positive regulation of amine transport|
|central nervous system neuron axonogenesis|
|postsynaptic signal transduction|
|regulation of dopamine secretion|
|positive regulation of B cell proliferation|
|excretion|
|visual learning|
|extracellular ligand-gated ion channel activity|
|regulation of action potential|
|response to nicotine|
|cranial nerve development|
|membrane depolarization|
|smooth muscle contraction|
|intraspecies interaction between organisms|
|social behavior|
|visual behavior|
|response to cocaine|
|integral component of presynaptic membrane|
|regulation of B cell proliferation|
|neural nucleus development|
|regulation of catecholamine secretion|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|multi-organism behavior|
|regulation of behavior|
|sensory perception of pain|
|diencephalon development|
|regulation of synaptic vesicle exocytosis|
|response to anesthetic|
|associative learning|
|nerve development|
|central nervous system neuron development|
|regulation of cellular amine metabolic process|
|feeding behavior|
|regulation of dendrite morphogenesis|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|action potential|
|regulation of response to drug|
|regulation of postsynaptic membrane potential|
|regulation of synapse assembly|
|regulation of neurotransmitter secretion|
|protein heterooligomerization|
|renal system process|
|regulation of synaptic vesicle cycle|
|response to alkaloid|
|regulation of circadian rhythm|
|memory|
|response to ethanol|
|positive regulation of lymphocyte proliferation|
|cellular response to ammonium ion|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of neurotransmitter transport|
|adult behavior|
|learning|
|sensory perception of sound|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|B cell activation|
|regulation of regulated secretory pathway|
|sensory perception of mechanical stimulus|
|positive regulation of B cell activation|
|central nervous system neuron differentiation|
|response to ammonium ion|
|locomotory behavior|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of synapse organization|
|visual perception|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|sensory perception of light stimulus|
|regulation of synapse structure or activity|
|response to alcohol|
|calcium ion transport|
|muscle contraction|
|learning or memory|
|synapse|
|positive regulation of ion transport|
|divalent metal ion transport|
|cognition|
|muscle system process|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|neuron projection|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|axonogenesis|
|response to oxygen levels|
|lymphocyte activation|
|forebrain development|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|cellular response to drug|
|axon development|
|positive regulation of cell activation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|response to toxic substance|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|protein complex oligomerization|
|cell junction|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|metal ion transport|
|regulation of cell activation|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|sensory perception|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.75|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6822
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNB2 Expression in NALM6 Cells: 0.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>