======= CHST12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHST12
  * **<color #00a2e8>Official Name</color>**: carbohydrate sulfotransferase 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55501|55501]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRB3|Q9NRB3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHST12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHST12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610129|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chondroitin 4-sulfotransferase activity|
|3-phosphoadenosine 5-phosphosulfate binding|
|dermatan sulfate biosynthetic process|
|dermatan sulfate metabolic process|
|dermatan sulfate proteoglycan biosynthetic process|
|dermatan sulfate proteoglycan metabolic process|
|chondroitin sulfate biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|sulfotransferase activity|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|integral component of Golgi membrane|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|carbohydrate biosynthetic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.72|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.1|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.37|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.42|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.44|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.76|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.83|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.85|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.91|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.03|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.47|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHST12 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>