======= CIAO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIAO1
  * **<color #00a2e8>Official Name</color>**: cytosolic iron-sulfur assembly component 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9391|9391]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76071|O76071]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CIAO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CIAO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604333|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000255|HAMAP-Rule:MF_03037, ECO:0000269|PubMed:17937914, ECO:0000269|PubMed:20797633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MMXD complex|
|CIA complex|
|protein maturation by iron-sulfur cluster transfer|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|cofactor biosynthetic process|
|protein maturation|
|chromosome segregation|
|sulfur compound metabolic process|
|cofactor metabolic process|
|positive regulation of cell population proliferation|
|regulation of cell population proliferation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2|
|[[:results:exp302|35°C R06 exp302]]|-1.92|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.79|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.76|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srp14|SRP14]]|0.418|
|[[:human genes:r:rfk|RFK]]|0.417|
|[[:human genes:t:thg1l|THG1L]]|0.414|
|[[:human genes:p:ppp4c|PPP4C]]|0.412|
|[[:human genes:r:rpp21|RPP21]]|0.409|
|[[:human genes:t:trmt5|TRMT5]]|0.408|
|[[:human genes:c:ccdc115|CCDC115]]|0.406|
|[[:human genes:a:adsl|ADSL]]|0.405|
|[[:human genes:r:rtcb|RTCB]]|0.403|
|[[:human genes:b:bub3|BUB3]]|0.403|
|[[:human genes:t:tti1|TTI1]]|0.401|
|[[:human genes:f:fh|FH]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 720/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|26/26|
|breast|29/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 227
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CIAO1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>