======= CIAPIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIAPIN1
  * **<color #00a2e8>Official Name</color>**: cytokine induced apoptosis inhibitor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57019|57019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6FI81|Q6FI81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CIAPIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CIAPIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CIAPIN1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|2 iron, 2 sulfur cluster binding|
|4 iron, 4 sulfur cluster binding|
|methyltransferase activity|
|electron transfer activity|
|mitochondrial intermembrane space|
|electron transport chain|
|cofactor biosynthetic process|
|methylation|
|sulfur compound metabolic process|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|oxidation-reduction process|
|negative regulation of cell death|
|programmed cell death|
|cell death|
|mitochondrion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.73|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.76|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmc1|PSMC1]]|0.475|
|[[:human genes:m:med14|MED14]]|0.47|
|[[:human genes:t:terf2|TERF2]]|0.459|
|[[:human genes:p:ppm1d|PPM1D]]|0.457|
|[[:human genes:p:psma6|PSMA6]]|0.444|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.442|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.435|
|[[:human genes:n:nup153|NUP153]]|0.431|
|[[:human genes:g:gid4|GID4]]|0.43|
|[[:human genes:m:med17|MED17]]|0.422|
|[[:human genes:z:znf655|ZNF655]]|0.42|
|[[:human genes:p:psmd1|PSMD1]]|0.419|
|[[:human genes:p:psmd13|PSMD13]]|0.419|
|[[:human genes:p:psmd7|PSMD7]]|0.418|
|[[:human genes:u:ubap1|UBAP1]]|0.41|
|[[:human genes:r:ranbp2|RANBP2]]|0.407|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.405|
|[[:human genes:d:dtl|DTL]]|0.404|
|[[:human genes:p:psmb4|PSMB4]]|0.403|
|[[:human genes:a:ankle2|ANKLE2]]|0.403|
|[[:human genes:m:myh2|MYH2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 524/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|25/28|
|bone|21/26|
|breast|23/33|
|central nervous system|43/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|16/21|
|liver|15/20|
|lung|47/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|12/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CIAPIN1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>