======= CITED2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CITED2
  * **<color #00a2e8>Official Name</color>**: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10370|10370]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99967|Q99967]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CITED2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CITED2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602937|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:15051727}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CITED|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adrenal cortex formation|
|adrenal cortex development|
|nodal signaling pathway involved in determination of left/right asymmetry|
|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry|
|embryonic heart tube left/right pattern formation|
|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|determination of left/right asymmetry in lateral mesoderm|
|LBD domain binding|
|positive regulation of male gonad development|
|regulation of male gonad development|
|positive regulation of peroxisome proliferator activated receptor signaling pathway|
|positive regulation of gonad development|
|nodal signaling pathway|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|lateral mesoderm development|
|left/right axis specification|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|regulation of gonad development|
|left/right pattern formation|
|sex determination|
|activin receptor signaling pathway|
|adrenal gland development|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|histone acetyltransferase binding|
|spleen development|
|response to fluid shear stress|
|regulation of animal organ formation|
|ventricular septum morphogenesis|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|response to estrogen|
|embryonic heart tube development|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|positive regulation of reproductive process|
|axis specification|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cardiac septum development|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|determination of left/right symmetry|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|endocrine system development|
|determination of bilateral symmetry|
|mesoderm development|
|specification of symmetry|
|regulation of DNA-templated transcription in response to stress|
|liver development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|hepaticobiliary system development|
|regulation of reproductive process|
|cardiac chamber development|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to oxygen levels|
|mesenchyme development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear chromatin|
|transcription corepressor activity|
|protein domain specific binding|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|transcription coactivator activity|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regionalization|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|response to oxygen levels|
|chromatin binding|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|embryonic organ development|
|pattern specification process|
|heart development|
|cell population proliferation|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|animal organ morphogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.83|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.81|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.73|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.81|
|[[:results:exp303|39°C R06 exp303]]|2.22|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.3|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10572
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CITED2 Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>