======= CKB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CKB
  * **<color #00a2e8>Official Name</color>**: creatine kinase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1152|1152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12277|P12277]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CKB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CKB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-gua Ptrans|
|ATP-gua PtransN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphagen biosynthetic process|
|phosphocreatine metabolic process|
|phosphagen metabolic process|
|cellular chloride ion homeostasis|
|phosphocreatine biosynthetic process|
|creatine kinase activity|
|creatine metabolic process|
|cellular monovalent inorganic anion homeostasis|
|cellular anion homeostasis|
|chloride ion homeostasis|
|monovalent inorganic anion homeostasis|
|substantia nigra development|
|cellular modified amino acid biosynthetic process|
|anion homeostasis|
|neural nucleus development|
|kinase activity|
|midbrain development|
|cerebellum development|
|metencephalon development|
|hindbrain development|
|cellular modified amino acid metabolic process|
|ubiquitin protein ligase binding|
|neuronal cell body|
|dendrite|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|cellular ion homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|ATP binding|
|extracellular space|
|homeostatic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.8|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CKB Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>