======= CKMT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CKMT2
  * **<color #00a2e8>Official Name</color>**: creatine kinase, mitochondrial 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1160|1160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17540|P17540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CKMT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CKMT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-gua Ptrans|
|ATP-gua PtransN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphagen metabolic process|
|phosphocreatine biosynthetic process|
|phosphagen biosynthetic process|
|phosphocreatine metabolic process|
|creatine kinase activity|
|creatine metabolic process|
|cellular modified amino acid biosynthetic process|
|kinase activity|
|cellular modified amino acid metabolic process|
|muscle contraction|
|muscle system process|
|mitochondrial inner membrane|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|ATP binding|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.94|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.9|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.71|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.7|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15744
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CKMT2 Expression in NALM6 Cells: 0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>