======= CLEC16A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLEC16A
  * **<color #00a2e8>Official Name</color>**: C-type lectin domain containing 16A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23274|23274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2KHT3|Q2KHT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLEC16A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLEC16A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FPL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of macroautophagy by TORC1 signaling|
|negative regulation of autophagosome maturation|
|negative regulation of mitophagy|
|positive regulation of autophagosome maturation|
|TORC1 signaling|
|negative regulation of autophagy of mitochondrion|
|regulation of autophagosome maturation|
|endolysosome membrane|
|positive regulation of TORC1 signaling|
|regulation of mitophagy|
|TOR signaling|
|negative regulation of macroautophagy|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of protein complex disassembly|
|positive regulation of TOR signaling|
|regulation of TORC1 signaling|
|regulation of autophagy of mitochondrion|
|negative regulation of ubiquitin-dependent protein catabolic process|
|endosome to lysosome transport|
|negative regulation of mitochondrion organization|
|negative regulation of proteasomal protein catabolic process|
|positive regulation of macroautophagy|
|negative regulation of protein complex disassembly|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of autophagy|
|negative regulation of cellular protein catabolic process|
|regulation of TOR signaling|
|lysosomal transport|
|regulation of protein complex disassembly|
|positive regulation of autophagy|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|late endosome|
|negative regulation of protein catabolic process|
|vacuolar transport|
|vesicle|
|Rab GTPase binding|
|cellular response to starvation|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|regulation of proteasomal protein catabolic process|
|response to starvation|
|regulation of proteolysis involved in cellular protein catabolic process|
|endosomal transport|
|cellular response to nutrient levels|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|negative regulation of catabolic process|
|regulation of autophagy|
|cellular response to external stimulus|
|negative regulation of proteolysis|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|molecular function|
|regulation of cellular catabolic process|
|Golgi apparatus|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|intracellular transport|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.36|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.99|
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.79|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arl5a|ARL5A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6797
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLEC16A Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>