======= CLIC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLIC4
  * **<color #00a2e8>Official Name</color>**: chloride intracellular channel 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25932|25932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y696|Q9Y696]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLIC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLIC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606536|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated ion channel activity|
|chloride channel complex|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|chloride channel activity|
|microvillus|
|apical part of cell|
|cellular response to calcium ion|
|intracellular|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|nuclear matrix|
|cytoplasmic vesicle membrane|
|response to calcium ion|
|microtubule cytoskeleton|
|midbody|
|inorganic anion transport|
|cell-cell junction|
|cellular response to metal ion|
|establishment or maintenance of cell polarity|
|actin cytoskeleton|
|cellular response to inorganic substance|
|negative regulation of cell migration|
|negative regulation of cell motility|
|keratinocyte differentiation|
|anion transmembrane transport|
|negative regulation of cellular component movement|
|epidermal cell differentiation|
|angiogenesis|
|negative regulation of locomotion|
|response to metal ion|
|skin development|
|blood vessel morphogenesis|
|epidermis development|
|regulation of ion transmembrane transport|
|blood vessel development|
|centrosome|
|vasculature development|
|cardiovascular system development|
|response to inorganic substance|
|regulation of cytoskeleton organization|
|regulation of transmembrane transport|
|anion transport|
|cell surface|
|inorganic ion transmembrane transport|
|tube morphogenesis|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|ion transmembrane transport|
|regulation of locomotion|
|regulation of cellular component movement|
|epithelium development|
|mitochondrion|
|transmembrane transport|
|regulation of organelle organization|
|ion transport|
|tissue development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.82|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.81|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.89|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLIC4 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>