======= CLTC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLTC
  * **<color #00a2e8>Official Name</color>**: clathrin heavy chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1213|1213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00610|Q00610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLTC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLTC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules.  The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clathrin propel|
|Clathrin|
|Clathrin-link|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic spindle microtubule|
|negative regulation of hyaluronan biosynthetic process|
|clathrin coat|
|clathrin coat of coated pit|
|clathrin coat of trans-Golgi network vesicle|
|amyloid-beta clearance by transcytosis|
|regulation of hyaluronan biosynthetic process|
|clathrin light chain binding|
|clathrin complex|
|low-density lipoprotein particle receptor catabolic process|
|low-density lipoprotein receptor particle metabolic process|
|endolysosome membrane|
|ubiquitin-specific protease binding|
|transcytosis|
|clathrin coat assembly|
|low-density lipoprotein particle receptor binding|
|negative regulation of protein localization to plasma membrane|
|amyloid-beta clearance|
|negative regulation of protein localization to cell periphery|
|low-density lipoprotein particle clearance|
|clathrin-dependent endocytosis|
|clathrin-coated endocytic vesicle|
|receptor catabolic process|
|negative regulation of protein localization to membrane|
|clathrin-coated endocytic vesicle membrane|
|disordered domain specific binding|
|transferrin transport|
|regulation of polysaccharide biosynthetic process|
|regulation of mitotic spindle organization|
|plasma lipoprotein particle clearance|
|regulation of spindle organization|
|regulation of polysaccharide metabolic process|
|negative regulation of carbohydrate metabolic process|
|extracellular vesicle|
|clathrin-coated vesicle|
|receptor internalization|
|iron ion transport|
|double-stranded RNA binding|
|regulation of plasma lipoprotein particle levels|
|mitotic spindle|
|negative regulation of small molecule metabolic process|
|retrograde transport, endosome to Golgi|
|trans-Golgi network membrane|
|regulation of carbohydrate biosynthetic process|
|regulation of protein localization to plasma membrane|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|melanosome|
|receptor metabolic process|
|regulation of establishment of planar polarity|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|spindle|
|transition metal ion transport|
|osteoblast differentiation|
|non-canonical Wnt signaling pathway|
|cytosolic transport|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of microtubule cytoskeleton organization|
|regulation of protein localization to membrane|
|antigen processing and presentation of peptide antigen|
|structural molecule activity|
|regulation of carbohydrate metabolic process|
|antigen processing and presentation|
|regulation of microtubule-based process|
|endosomal transport|
|receptor-mediated endocytosis|
|lysosome|
|regulation of animal organ morphogenesis|
|process utilizing autophagic mechanism|
|ossification|
|autophagy|
|endosome|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|focal adhesion|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|protein kinase binding|
|cell division|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|endocytosis|
|protein-containing complex|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|metal ion transport|
|import into cell|
|protein catabolic process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|regulation of cell cycle process|
|cation transport|
|cellular protein-containing complex assembly|
|membrane organization|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|ion transport|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.96|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.91|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.76|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.73|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.72|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.75|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.84|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gak|GAK]]|0.438|
|[[:human genes:p:pds5b|PDS5B]]|0.417|
|[[:human genes:t:tacc3|TACC3]]|0.414|
|[[:human genes:w:wbp11|WBP11]]|0.41|
|[[:human genes:u:ube4b|UBE4B]]|0.403|
|[[:human genes:c:ckap5|CKAP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 718/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|23/26|
|breast|32/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLTC Expression in NALM6 Cells: 10.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>