======= CMC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMC2
  * **<color #00a2e8>Official Name</color>**: C-X9-C motif containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56942|56942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRP2|Q9NRP2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cmc1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.66|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.43|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.34|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.2|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.18|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.16|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.13|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.07|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.01|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.99|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.89|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.8|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.7|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.83|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.83|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.85|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.91|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.05|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.08|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.2|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.38|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.46|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMC2 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>