======= CNGB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNGB1
  * **<color #00a2e8>Official Name</color>**: cyclic nucleotide gated channel subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1258|1258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14028|Q14028]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNGB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNGB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600724|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cNMP binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular cyclic nucleotide activated cation channel complex|
|transmembrane transporter complex|
|intracellular cGMP-activated cation channel activity|
|intracellular cAMP-activated cation channel activity|
|photoreceptor cell outer segment organization|
|rhodopsin mediated signaling pathway|
|ligand-gated ion channel activity|
|cGMP binding|
|detection of light stimulus involved in sensory perception|
|detection of light stimulus involved in visual perception|
|phototransduction, visible light|
|Golgi-associated vesicle membrane|
|cAMP binding|
|regulation of rhodopsin mediated signaling pathway|
|protein heterotetramerization|
|photoreceptor cell maintenance|
|phototransduction|
|photoreceptor cell development|
|detection of visible light|
|terminal bouton|
|ciliary membrane|
|photoreceptor cell differentiation|
|detection of light stimulus|
|photoreceptor outer segment|
|retina homeostasis|
|protein heterooligomerization|
|cellular response to light stimulus|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of G protein-coupled receptor signaling pathway|
|protein tetramerization|
|cellular response to radiation|
|tissue homeostasis|
|visual perception|
|sensory perception of light stimulus|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|cellular calcium ion homeostasis|
|response to radiation|
|calcium ion homeostasis|
|sensory perception of smell|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|cellular metal ion homeostasis|
|cation transmembrane transport|
|Golgi membrane|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|sensory perception|
|neuron differentiation|
|regulation of response to external stimulus|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|homeostatic process|
|cell development|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNGB1 Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>