======= CNIH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNIH2
  * **<color #00a2e8>Official Name</color>**: cornichon family AMPA receptor auxiliary protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=254263|254263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PI25|Q6PI25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNIH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNIH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611288|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cornichon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of synaptic vesicle transport|
|negative regulation of vesicle transport along microtubule|
|negative regulation of anterograde synaptic vesicle transport|
|negative regulation of receptor localization to synapse|
|regulation of anterograde synaptic vesicle transport|
|regulation of vesicle transport along microtubule|
|regulation of synaptic vesicle transport|
|regulation of organelle transport along microtubule|
|regulation of postsynaptic neurotransmitter receptor activity|
|regulation of receptor localization to synapse|
|regulation of AMPA receptor activity|
|regulation of protein localization to synapse|
|AMPA glutamate receptor complex|
|synaptic transmission, glutamatergic|
|regulation of microtubule-based movement|
|dendritic shaft|
|regulation of NMDA receptor activity|
|integral component of postsynaptic density membrane|
|ER to Golgi transport vesicle membrane|
|negative regulation of intracellular transport|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|regulation of glutamate receptor signaling pathway|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|regulation of neurotransmitter receptor activity|
|Golgi vesicle budding|
|localization within membrane|
|vesicle targeting|
|vesicle budding from membrane|
|regulation of nervous system process|
|dendritic spine|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|establishment of vesicle localization|
|vesicle localization|
|postsynaptic membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of microtubule-based process|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|vesicle organization|
|negative regulation of cellular component movement|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|regulation of intracellular transport|
|establishment of organelle localization|
|Golgi vesicle transport|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|cell junction|
|regulation of transmembrane transport|
|organelle localization|
|regulation of system process|
|Golgi membrane|
|regulation of ion transport|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of cellular component movement|
|regulation of protein localization|
|cell-cell signaling|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.11|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.85|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNIH2 Expression in NALM6 Cells: -1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>