======= CNN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNN1
  * **<color #00a2e8>Official Name</color>**: calponin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1264|1264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51911|P51911]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|Calponin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular smooth muscle cell proliferation|
|negative regulation of smooth muscle cell proliferation|
|regulation of vascular smooth muscle cell proliferation|
|regulation of smooth muscle contraction|
|actomyosin structure organization|
|regulation of smooth muscle cell proliferation|
|regulation of muscle contraction|
|calmodulin binding|
|regulation of muscle system process|
|actin binding|
|cytoskeleton|
|focal adhesion|
|actin cytoskeleton organization|
|actin filament-based process|
|regulation of system process|
|negative regulation of cell population proliferation|
|cytoskeleton organization|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.07|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.89|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.79|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.78|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.76|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16127
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNN1 Expression in NALM6 Cells: 0.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>