======= CNTNAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNTNAP1
  * **<color #00a2e8>Official Name</color>**: contactin associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8506|8506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78357|P78357]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNTNAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNTNAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602346|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. {ECO:0000269|PubMed:24319099, ECO:0000269|PubMed:27818385, ECO:0000269|PubMed:28374019}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Laminin G 2|
|F5 F8 type C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to paranode region of axon|
|protein localization to juxtaparanode region of axon|
|paranodal junction assembly|
|paranodal junction|
|action potential propagation|
|protein localization to axon|
|neuronal action potential propagation|
|presynaptic active zone membrane|
|paranode region of axon|
|neuromuscular process controlling posture|
|myelin assembly|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|Schwann cell development|
|Schwann cell differentiation|
|oligodendrocyte development|
|neuromuscular process controlling balance|
|SH3/SH2 adaptor activity|
|transmission of nerve impulse|
|oligodendrocyte differentiation|
|peripheral nervous system development|
|action potential|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myelination|
|glial cell development|
|ensheathment of neurons|
|neuromuscular process|
|axon ensheathment|
|SH3 domain binding|
|multicellular organismal signaling|
|cell-cell junction organization|
|cell junction assembly|
|glial cell differentiation|
|signaling receptor activity|
|gliogenesis|
|cell junction organization|
|regulation of membrane potential|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNTNAP1 Expression in NALM6 Cells: 2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>