======= COA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COA6
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388753|388753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JTJ3|Q5JTJ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614772|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX6B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane ATP synthesis coupled electron transport|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|copper ion binding|
|mitochondrial intermembrane space|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|generation of precursor metabolites and energy|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.75|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.79|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.8|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.89|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.92|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.95|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.01|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.01|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.13|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.13|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.19|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.25|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.675|
|[[:human genes:c:coa3|COA3]]|0.646|
|[[:human genes:e:ears2|EARS2]]|0.63|
|[[:human genes:q:qrsl1|QRSL1]]|0.625|
|[[:human genes:p:pet117|PET117]]|0.621|
|[[:human genes:y:yars2|YARS2]]|0.611|
|[[:human genes:f:fastkd5|FASTKD5]]|0.609|
|[[:human genes:s:sco2|SCO2]]|0.608|
|[[:human genes:t:tars2|TARS2]]|0.608|
|[[:human genes:c:cox11|COX11]]|0.601|
|[[:human genes:m:mrpl53|MRPL53]]|0.598|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.595|
|[[:human genes:v:vars2|VARS2]]|0.593|
|[[:human genes:c:cox15|COX15]]|0.591|
|[[:human genes:n:nars2|NARS2]]|0.587|
|[[:human genes:c:cox16|COX16]]|0.583|
|[[:human genes:m:mrps34|MRPS34]]|0.58|
|[[:human genes:m:mrps21|MRPS21]]|0.572|
|[[:human genes:d:dap3|DAP3]]|0.57|
|[[:human genes:r:rpusd4|RPUSD4]]|0.57|
|[[:human genes:p:pet112|PET112]]|0.569|
|[[:human genes:m:mrps16|MRPS16]]|0.567|
|[[:human genes:m:mrps26|MRPS26]]|0.565|
|[[:human genes:c:coq2|COQ2]]|0.564|
|[[:human genes:g:gfm2|GFM2]]|0.562|
|[[:human genes:m:mrps6|MRPS6]]|0.562|
|[[:human genes:p:pars2|PARS2]]|0.56|
|[[:human genes:c:cars2|CARS2]]|0.558|
|[[:human genes:l:lars2|LARS2]]|0.552|
|[[:human genes:m:mrps25|MRPS25]]|0.551|
|[[:human genes:m:mrps5|MRPS5]]|0.55|
|[[:human genes:c:c12orf65|C12orf65]]|0.545|
|[[:human genes:a:aars2|AARS2]]|0.544|
|[[:human genes:g:gfm1|GFM1]]|0.534|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.533|
|[[:human genes:m:mcat|MCAT]]|0.53|
|[[:human genes:m:mrpl23|MRPL23]]|0.528|
|[[:human genes:m:mrpl21|MRPL21]]|0.528|
|[[:human genes:m:mrpl47|MRPL47]]|0.528|
|[[:human genes:s:sars2|SARS2]]|0.526|
|[[:human genes:m:mtpap|MTPAP]]|0.523|
|[[:human genes:r:rpusd3|RPUSD3]]|0.523|
|[[:human genes:m:mtg2|MTG2]]|0.523|
|[[:human genes:m:mrps2|MRPS2]]|0.523|
|[[:human genes:m:mettl17|METTL17]]|0.517|
|[[:human genes:r:rars2|RARS2]]|0.516|
|[[:human genes:b:bcs1l|BCS1L]]|0.516|
|[[:human genes:w:wbscr16|WBSCR16]]|0.515|
|[[:human genes:m:mrps12|MRPS12]]|0.511|
|[[:human genes:l:lrpprc|LRPPRC]]|0.51|
|[[:human genes:m:mrps24|MRPS24]]|0.508|
|[[:human genes:r:rbfa|RBFA]]|0.508|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.503|
|[[:human genes:c:cox17|COX17]]|0.503|
|[[:human genes:c:cox20|COX20]]|0.503|
|[[:human genes:m:mrps18a|MRPS18A]]|0.501|
|[[:human genes:m:mrpl45|MRPL45]]|0.499|
|[[:human genes:m:mrps35|MRPS35]]|0.497|
|[[:human genes:d:dars2|DARS2]]|0.497|
|[[:human genes:m:mrps14|MRPS14]]|0.497|
|[[:human genes:m:mrp63|MRP63]]|0.496|
|[[:human genes:n:ndufa3|NDUFA3]]|0.494|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.493|
|[[:human genes:m:mars2|MARS2]]|0.493|
|[[:human genes:m:mrps10|MRPS10]]|0.492|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.491|
|[[:human genes:c:cox6b1|COX6B1]]|0.489|
|[[:human genes:g:gatc|GATC]]|0.488|
|[[:human genes:f:fars2|FARS2]]|0.486|
|[[:human genes:f:ftsj2|FTSJ2]]|0.486|
|[[:human genes:p:polg2|POLG2]]|0.485|
|[[:human genes:m:mrps27|MRPS27]]|0.48|
|[[:human genes:m:mrpl15|MRPL15]]|0.479|
|[[:human genes:w:wars2|WARS2]]|0.478|
|[[:human genes:h:hars2|HARS2]]|0.477|
|[[:human genes:m:mrpl20|MRPL20]]|0.474|
|[[:human genes:m:mrpl37|MRPL37]]|0.472|
|[[:human genes:c:cox7b|COX7B]]|0.471|
|[[:human genes:n:ndufb11|NDUFB11]]|0.471|
|[[:human genes:h:higd2a|HIGD2A]]|0.471|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.469|
|[[:human genes:a:aifm1|AIFM1]]|0.465|
|[[:human genes:n:ndufa2|NDUFA2]]|0.465|
|[[:human genes:m:malsu1|MALSU1]]|0.464|
|[[:human genes:m:mrpl44|MRPL44]]|0.463|
|[[:human genes:m:mrpl11|MRPL11]]|0.463|
|[[:human genes:c:cox6c|COX6C]]|0.463|
|[[:human genes:p:pnpt1|PNPT1]]|0.463|
|[[:human genes:m:mrpl3|MRPL3]]|0.458|
|[[:human genes:e:eral1|ERAL1]]|0.457|
|[[:human genes:t:tefm|TEFM]]|0.457|
|[[:human genes:s:slc31a1|SLC31A1]]|0.457|
|[[:human genes:m:mrpl4|MRPL4]]|0.456|
|[[:human genes:e:ecsit|ECSIT]]|0.456|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.454|
|[[:human genes:p:ptcd3|PTCD3]]|0.452|
|[[:human genes:d:ddx28|DDX28]]|0.451|
|[[:human genes:m:mrpl2|MRPL2]]|0.45|
|[[:human genes:m:mrpl12|MRPL12]]|0.45|
|[[:human genes:p:polg|POLG]]|0.45|
|[[:human genes:m:mtif2|MTIF2]]|0.449|
|[[:human genes:t:timm8b|TIMM8B]]|0.447|
|[[:human genes:t:tmem242|TMEM242]]|0.445|
|[[:human genes:m:mto1|MTO1]]|0.443|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.442|
|[[:human genes:f:fastkd1|FASTKD1]]|0.441|
|[[:human genes:m:mtg1|MTG1]]|0.441|
|[[:human genes:n:ndufa1|NDUFA1]]|0.44|
|[[:human genes:f:fastkd2|FASTKD2]]|0.44|
|[[:human genes:n:ndufs2|NDUFS2]]|0.44|
|[[:human genes:t:tfb1m|TFB1M]]|0.439|
|[[:human genes:m:mrpl49|MRPL49]]|0.439|
|[[:human genes:t:tmem261|TMEM261]]|0.437|
|[[:human genes:m:mrpl55|MRPL55]]|0.437|
|[[:human genes:p:pdss1|PDSS1]]|0.437|
|[[:human genes:m:mrps23|MRPS23]]|0.436|
|[[:human genes:t:trub2|TRUB2]]|0.435|
|[[:human genes:m:mrpl43|MRPL43]]|0.435|
|[[:human genes:c:cox19|COX19]]|0.435|
|[[:human genes:m:mrps9|MRPS9]]|0.434|
|[[:human genes:c:coq4|COQ4]]|0.432|
|[[:human genes:s:slc25a26|SLC25A26]]|0.432|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.431|
|[[:human genes:c:cox18|COX18]]|0.429|
|[[:human genes:m:mrps33|MRPS33]]|0.429|
|[[:human genes:m:mterfd1|MTERFD1]]|0.428|
|[[:human genes:m:mrpl1|MRPL1]]|0.428|
|[[:human genes:c:coa5|COA5]]|0.427|
|[[:human genes:f:fastkd3|FASTKD3]]|0.426|
|[[:human genes:m:mrps7|MRPS7]]|0.425|
|[[:human genes:m:mrpl36|MRPL36]]|0.424|
|[[:human genes:d:dhx30|DHX30]]|0.424|
|[[:human genes:m:mrpl35|MRPL35]]|0.423|
|[[:human genes:m:mtif3|MTIF3]]|0.422|
|[[:human genes:s:sco1|SCO1]]|0.421|
|[[:human genes:m:mrpl27|MRPL27]]|0.42|
|[[:human genes:f:foxred1|FOXRED1]]|0.42|
|[[:human genes:t:tomm20|TOMM20]]|0.419|
|[[:human genes:p:pitrm1|PITRM1]]|0.419|
|[[:human genes:p:pet100|PET100]]|0.419|
|[[:human genes:m:mrpl18|MRPL18]]|0.418|
|[[:human genes:m:mrps11|MRPS11]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.416|
|[[:human genes:p:polrmt|POLRMT]]|0.416|
|[[:human genes:m:mrpl39|MRPL39]]|0.413|
|[[:human genes:c:cox7c|COX7C]]|0.413|
|[[:human genes:a:acad9|ACAD9]]|0.412|
|[[:human genes:c:coq5|COQ5]]|0.412|
|[[:human genes:m:mrpl17|MRPL17]]|0.408|
|[[:human genes:n:ndufc2|NDUFC2]]|0.407|
|[[:human genes:n:ndufb6|NDUFB6]]|0.407|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.406|
|[[:human genes:c:coq3|COQ3]]|0.406|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.404|
|[[:human genes:m:mipep|MIPEP]]|0.404|
|[[:human genes:c:chchd4|CHCHD4]]|0.403|
|[[:human genes:m:minos1|MINOS1]]|0.403|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.403|
|[[:human genes:m:mrps22|MRPS22]]|0.402|
|[[:human genes:m:mrpl42|MRPL42]]|0.401|
|[[:human genes:c:clpp|CLPP]]|0.4|
|[[:human genes:c:chchd1|CHCHD1]]|0.4|
|[[:human genes:c:coq7|COQ7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COA6 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>