======= COG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG2
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22796|22796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14746|Q14746]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi morphology and function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3510|
|COG2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|intra-Golgi vesicle-mediated transport|
|Golgi stack|
|trans-Golgi network membrane|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein-containing complex binding|
|Golgi vesicle transport|
|endomembrane system organization|
|Golgi membrane|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.49|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.34|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.3|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.2|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.19|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.15|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.04|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.03|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.99|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.95|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.89|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.86|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.74|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.74|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.71|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog8|COG8]]|0.486|
|[[:human genes:r:rrm1|RRM1]]|0.441|
|[[:human genes:w:wrb|WRB]]|0.44|
|[[:human genes:c:cog7|COG7]]|0.439|
|[[:human genes:s:scap|SCAP]]|0.428|
|[[:human genes:g:get4|GET4]]|0.422|
|[[:human genes:c:cog3|COG3]]|0.414|
|[[:human genes:c:cog6|COG6]]|0.408|
|[[:human genes:u:uso1|USO1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 85/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|4/28|
|bone|3/26|
|breast|1/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|4/21|
|liver|2/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>