======= COG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG3
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83548|83548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JB2|Q96JB2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ER-Golgi transport. {ECO:0000269|PubMed:11929878}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|intra-Golgi vesicle-mediated transport|
|cis-Golgi network|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|trans-Golgi network membrane|
|Golgi cisterna membrane|
|Golgi organization|
|protein stabilization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|regulation of protein stability|
|glycoprotein biosynthetic process|
|Golgi vesicle transport|
|glycoprotein metabolic process|
|endomembrane system organization|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|protein localization to organelle|
|Golgi apparatus|
|intracellular protein transport|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.58|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.44|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.32|
|[[:results:exp539|42°C R08 exp539]]|-2.26|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.09|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.07|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.05|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.03|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.01|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.89|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.84|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.83|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.81|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.74|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.71|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.7|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog4|COG4]]|0.533|
|[[:human genes:c:cog1|COG1]]|0.49|
|[[:human genes:c:cog7|COG7]]|0.439|
|[[:human genes:p:prim1|PRIM1]]|0.432|
|[[:human genes:c:cog2|COG2]]|0.414|
|[[:human genes:c:cog8|COG8]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 499/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|16/28|
|bone|14/26|
|breast|17/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|9/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|21/21|
|liver|17/20|
|lung|52/75|
|lymphocyte|12/16|
|ovary|17/26|
|pancreas|19/24|
|peripheral nervous system|4/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG3 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>