======= COG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG5
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10466|10466]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UP83|Q9UP83]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606821|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi function. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps51|
|COG5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|intra-Golgi vesicle-mediated transport|
|trans-Golgi network membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|Golgi membrane|
|molecular function|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.45|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.98|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.59|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.49|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.45|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.42|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.19|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.17|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.12|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.02|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.98|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.94|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.91|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.9|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:unc50|UNC50]]|0.613|
|[[:human genes:c:cog7|COG7]]|0.611|
|[[:human genes:g:gpr107|GPR107]]|0.549|
|[[:human genes:a:arl1|ARL1]]|0.536|
|[[:human genes:m:mbtps1|MBTPS1]]|0.501|
|[[:human genes:s:sgms1|SGMS1]]|0.482|
|[[:human genes:c:chka|CHKA]]|0.477|
|[[:human genes:s:scap|SCAP]]|0.461|
|[[:human genes:c:cog6|COG6]]|0.459|
|[[:human genes:t:tbc1d22b|TBC1D22B]]|0.436|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.433|
|[[:human genes:r:rab1b|RAB1B]]|0.433|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.43|
|[[:human genes:w:wdr7|WDR7]]|0.427|
|[[:human genes:j:jtb|JTB]]|0.427|
|[[:human genes:c:c10orf76|C10orf76]]|0.425|
|[[:human genes:r:rgp1|RGP1]]|0.413|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.412|
|[[:human genes:z:zfat|ZFAT]]|0.411|
|[[:human genes:d:dmxl1|DMXL1]]|0.407|
|[[:human genes:s:scyl1|SCYL1]]|0.402|
|[[:human genes:d:dym|DYM]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG5 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>