======= COG6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG6
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57511|57511]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2V7|Q9Y2V7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi function. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COG6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|intra-Golgi vesicle-mediated transport|
|trans-Golgi network membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|glycosylation|
|Golgi vesicle transport|
|Golgi membrane|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.11|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.82|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.42|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.33|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.28|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.22|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.18|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.13|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.07|
|[[:results:exp539|42°C R08 exp539]]|-1.87|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.82|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.82|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.8|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.77|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog7|COG7]]|0.584|
|[[:human genes:u:unc50|UNC50]]|0.546|
|[[:human genes:r:rab1b|RAB1B]]|0.532|
|[[:human genes:c:cog5|COG5]]|0.459|
|[[:human genes:g:gpr107|GPR107]]|0.436|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.427|
|[[:human genes:s:scyl1|SCYL1]]|0.417|
|[[:human genes:m:mtmr6|MTMR6]]|0.415|
|[[:human genes:c:cog2|COG2]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG6 Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>