======= COL18A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL18A1
  * **<color #00a2e8>Official Name</color>**: collagen type XVIII alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80781|80781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39060|P39060]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL18A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL18A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120328|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endostatin|
|Fz|
|DUF959|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to hydrostatic pressure|
|endothelial cell morphogenesis|
|response to water|
|positive regulation of endothelial cell apoptotic process|
|positive regulation of epithelial cell apoptotic process|
|epithelial cell morphogenesis|
|extracellular matrix structural constituent conferring tensile strength|
|regulation of endothelial cell apoptotic process|
|endothelial cell development|
|collagen trimer|
|regulation of epithelial cell apoptotic process|
|endothelial cell differentiation|
|basement membrane|
|endothelium development|
|extracellular matrix structural constituent|
|epithelial cell development|
|visual perception|
|sensory perception of light stimulus|
|extracellular matrix|
|endoplasmic reticulum lumen|
|angiogenesis|
|extracellular matrix organization|
|response to acid chemical|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood vessel morphogenesis|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|positive regulation of cell death|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|sensory perception|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|epithelium development|
|response to abiotic stimulus|
|nervous system process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|cell development|
|regulation of cell death|
|tissue development|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.24|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.06|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.01|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.01|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.72|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL18A1 Expression in NALM6 Cells: 2.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>