======= COL28A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL28A1
  * **<color #00a2e8>Official Name</color>**: collagen type XXVIII alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340267|340267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2UY09|Q2UY09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL28A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL28A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609996|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a cell-binding protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|Kunitz BPTI|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular matrix structural constituent conferring tensile strength|
|collagen trimer|
|basement membrane|
|serine-type endopeptidase inhibitor activity|
|extracellular matrix structural constituent|
|extracellular matrix|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|endoplasmic reticulum lumen|
|extracellular matrix organization|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|cell adhesion|
|biological adhesion|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|extracellular space|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.06|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.72|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.88|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.02|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.02|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.15|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.91|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.93|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|3|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.585|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL28A1 Expression in NALM6 Cells: 2.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>