======= COMMD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMMD1
  * **<color #00a2e8>Official Name</color>**: copper metabolism domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150684|150684]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N668|Q8N668]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMMD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMMD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607238|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). {ECO:0000269|PubMed:14645214, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:17183367, ECO:0000269|PubMed:17309234, ECO:0000269|PubMed:20048074, ECO:0000269|PubMed:20237237, ECO:0000269|PubMed:20458141, ECO:0000269|PubMed:20595380, ECO:0000269|PubMed:21483833, ECO:0000269|PubMed:21741370, ECO:0000269|PubMed:21778237, ECO:0000269|PubMed:23515529, ECO:0000269|PubMed:25355947}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HCaRG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane to endosome transport|
|negative regulation of sodium ion transmembrane transport|
|negative regulation of protein localization to cell surface|
|Cul2-RING ubiquitin ligase complex|
|copper ion homeostasis|
|negative regulation of sodium ion transport|
|phosphatidic acid binding|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|regulation of protein localization to cell surface|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|copper ion binding|
|Golgi to plasma membrane transport|
|regulation of sodium ion transmembrane transport|
|phosphatidylinositol-4,5-bisphosphate binding|
|negative regulation of cation transmembrane transport|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of sodium ion transport|
|vesicle-mediated transport to the plasma membrane|
|negative regulation of ion transmembrane transport|
|post-Golgi vesicle-mediated transport|
|negative regulation of cellular protein localization|
|positive regulation of protein ubiquitination|
|recycling endosome|
|negative regulation of transmembrane transport|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|transition metal ion homeostasis|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of ion transport|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of DNA-binding transcription factor activity|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|endosome membrane|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cellular protein catabolic process|
|early endosome|
|endosome|
|regulation of cation transmembrane transport|
|post-translational protein modification|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of DNA-binding transcription factor activity|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|metal ion homeostasis|
|protein ubiquitination|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|ion homeostasis|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of protein localization|
|identical protein binding|
|chemical homeostasis|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|protein transport|
|peptide transport|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of protein metabolic process|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMMD1 Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>