======= COPB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPB1
  * **<color #00a2e8>Official Name</color>**: COPI coat complex subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1315|1315]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53618|P53618]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600959|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa- type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Adaptin N|
|Coatamer beta C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI vesicle coat|
|Golgi-associated vesicle|
|intra-Golgi vesicle-mediated transport|
|ficolin-1-rich granule membrane|
|tertiary granule membrane|
|endoplasmic reticulum-Golgi intermediate compartment|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|secretory granule membrane|
|structural molecule activity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|viral process|
|regulated exocytosis|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|leukocyte activation|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.64|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.42|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.29|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.22|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.02|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.02|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.98|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.79|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.79|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.74|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.73|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.8|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.81|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.82|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.98|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.01|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.04|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.05|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.06|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.08|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.1|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.11|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.13|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.26|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.4|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.4|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.53|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.589|
|[[:human genes:t:ticrr|TICRR]]|0.561|
|[[:human genes:c:copb2|COPB2]]|0.56|
|[[:human genes:a:arcn1|ARCN1]]|0.555|
|[[:human genes:c:copg1|COPG1]]|0.524|
|[[:human genes:c:chd4|CHD4]]|0.524|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.518|
|[[:human genes:n:nupl1|NUPL1]]|0.514|
|[[:human genes:s:supt5h|SUPT5H]]|0.514|
|[[:human genes:n:npipb5|NPIPB5]]|0.512|
|[[:human genes:p:pan3|PAN3]]|0.501|
|[[:human genes:z:znf655|ZNF655]]|0.5|
|[[:human genes:o:osbp|OSBP]]|0.5|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.5|
|[[:human genes:p:polr2j3|POLR2J3]]|0.499|
|[[:human genes:p:psma6|PSMA6]]|0.497|
|[[:human genes:t:tfip11|TFIP11]]|0.495|
|[[:human genes:p:psmb4|PSMB4]]|0.493|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.493|
|[[:human genes:t:tceb3c|TCEB3C]]|0.493|
|[[:human genes:a:aamp|AAMP]]|0.492|
|[[:human genes:s:supt6h|SUPT6H]]|0.491|
|[[:human genes:u:upf1|UPF1]]|0.489|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.489|
|[[:human genes:o:orc6|ORC6]]|0.489|
|[[:human genes:g:gid4|GID4]]|0.488|
|[[:human genes:m:mt1e|MT1E]]|0.487|
|[[:human genes:c:cbwd3|CBWD3]]|0.487|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.486|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.483|
|[[:human genes:v:vps54|VPS54]]|0.482|
|[[:human genes:c:copz1|COPZ1]]|0.479|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.479|
|[[:human genes:r:rpl35|RPL35]]|0.478|
|[[:human genes:t:tyms|TYMS]]|0.476|
|[[:human genes:p:psmd3|PSMD3]]|0.475|
|[[:human genes:c:cln6|CLN6]]|0.475|
|[[:human genes:p:paf1|PAF1]]|0.475|
|[[:human genes:m:med14|MED14]]|0.474|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.472|
|[[:human genes:n:nbpf10|NBPF10]]|0.471|
|[[:human genes:c:cactin|CACTIN]]|0.471|
|[[:human genes:c:cbwd6|CBWD6]]|0.469|
|[[:human genes:c:chaf1a|CHAF1A]]|0.468|
|[[:human genes:s:slc4a1|SLC4A1]]|0.467|
|[[:human genes:d:dtl|DTL]]|0.467|
|[[:human genes:o:orc1|ORC1]]|0.467|
|[[:human genes:r:rpl14|RPL14]]|0.465|
|[[:human genes:t:timeless|TIMELESS]]|0.465|
|[[:human genes:c:cdca3|CDCA3]]|0.464|
|[[:human genes:e:exosc3|EXOSC3]]|0.461|
|[[:human genes:p:psmc1|PSMC1]]|0.461|
|[[:human genes:p:psma7|PSMA7]]|0.459|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.457|
|[[:human genes:s:slc6a17|SLC6A17]]|0.457|
|[[:human genes:p:polr1a|POLR1A]]|0.457|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.457|
|[[:human genes:l:lrr1|LRR1]]|0.457|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.456|
|[[:human genes:n:nol10|NOL10]]|0.456|
|[[:human genes:r:rrp15|RRP15]]|0.456|
|[[:human genes:y:ythdc1|YTHDC1]]|0.455|
|[[:human genes:a:ankle2|ANKLE2]]|0.455|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.455|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.454|
|[[:human genes:n:napa|NAPA]]|0.454|
|[[:human genes:p:pan2|PAN2]]|0.453|
|[[:human genes:r:rpl34|RPL34]]|0.453|
|[[:human genes:s:sec13|SEC13]]|0.452|
|[[:human genes:w:wdr43|WDR43]]|0.451|
|[[:human genes:n:nup160|NUP160]]|0.451|
|[[:human genes:p:psmc6|PSMC6]]|0.451|
|[[:human genes:s:snrpa1|SNRPA1]]|0.451|
|[[:human genes:r:rad51|RAD51]]|0.451|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.45|
|[[:human genes:s:sf3a1|SF3A1]]|0.45|
|[[:human genes:d:ddt|DDT]]|0.45|
|[[:human genes:r:rfpl3|RFPL3]]|0.449|
|[[:human genes:d:ddtl|DDTL]]|0.449|
|[[:human genes:c:cbwd5|CBWD5]]|0.449|
|[[:human genes:v:vasn|VASN]]|0.447|
|[[:human genes:r:rps2|RPS2]]|0.445|
|[[:human genes:p:psmb2|PSMB2]]|0.445|
|[[:human genes:c:copa|COPA]]|0.444|
|[[:human genes:e:exosc9|EXOSC9]]|0.444|
|[[:human genes:s:smg1|SMG1]]|0.444|
|[[:human genes:p:pole|POLE]]|0.443|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.442|
|[[:human genes:s:sf3a3|SF3A3]]|0.442|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.438|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.438|
|[[:human genes:p:polr2a|POLR2A]]|0.437|
|[[:human genes:u:uqcrh|UQCRH]]|0.437|
|[[:human genes:s:smg7|SMG7]]|0.436|
|[[:human genes:a:aqr|AQR]]|0.436|
|[[:human genes:s:sart1|SART1]]|0.435|
|[[:human genes:t:twistnb|TWISTNB]]|0.434|
|[[:human genes:h:hmgcr|HMGCR]]|0.434|
|[[:human genes:n:nup62|NUP62]]|0.432|
|[[:human genes:i:igfn1|IGFN1]]|0.431|
|[[:human genes:c:cope|COPE]]|0.431|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.43|
|[[:human genes:r:rpl30|RPL30]]|0.43|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.429|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.429|
|[[:human genes:c:ccna2|CCNA2]]|0.428|
|[[:human genes:t:tagln|TAGLN]]|0.426|
|[[:human genes:p:pex5|PEX5]]|0.426|
|[[:human genes:p:pwp2|PWP2]]|0.426|
|[[:human genes:t:trappc8|TRAPPC8]]|0.425|
|[[:human genes:f:fcn2|FCN2]]|0.425|
|[[:human genes:n:nol8|NOL8]]|0.425|
|[[:human genes:c:c14orf93|C14orf93]]|0.424|
|[[:human genes:m:med29|MED29]]|0.424|
|[[:human genes:m:mylk3|MYLK3]]|0.424|
|[[:human genes:p:ppm1d|PPM1D]]|0.424|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.423|
|[[:human genes:f:fam160a1|FAM160A1]]|0.423|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.423|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.422|
|[[:human genes:e:exosc5|EXOSC5]]|0.421|
|[[:human genes:r:rpl6|RPL6]]|0.421|
|[[:human genes:n:nup153|NUP153]]|0.42|
|[[:human genes:s:sap30bp|SAP30BP]]|0.419|
|[[:human genes:p:psmc2|PSMC2]]|0.419|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.418|
|[[:human genes:d:dock6|DOCK6]]|0.418|
|[[:human genes:c:cep192|CEP192]]|0.417|
|[[:human genes:i:ik|IK]]|0.417|
|[[:human genes:p:psmc4|PSMC4]]|0.417|
|[[:human genes:c:commd4|COMMD4]]|0.417|
|[[:human genes:g:gar1|GAR1]]|0.416|
|[[:human genes:n:nup205|NUP205]]|0.416|
|[[:human genes:d:dhx38|DHX38]]|0.416|
|[[:human genes:c:chmp2a|CHMP2A]]|0.416|
|[[:human genes:z:zfand5|ZFAND5]]|0.416|
|[[:human genes:a:acsf2|ACSF2]]|0.415|
|[[:human genes:m:myo1h|MYO1H]]|0.414|
|[[:human genes:r:rrn3|RRN3]]|0.413|
|[[:human genes:z:znf574|ZNF574]]|0.412|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.412|
|[[:human genes:a:aatf|AATF]]|0.411|
|[[:human genes:l:loc643669|LOC643669]]|0.411|
|[[:human genes:o:or10g3|OR10G3]]|0.411|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.41|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.41|
|[[:human genes:k:kpnb1|KPNB1]]|0.409|
|[[:human genes:o:ogfr|OGFR]]|0.409|
|[[:human genes:n:npipb3|NPIPB3]]|0.408|
|[[:human genes:n:nop16|NOP16]]|0.408|
|[[:human genes:r:rad21|RAD21]]|0.408|
|[[:human genes:t:tspy1|TSPY1]]|0.408|
|[[:human genes:u:utp3|UTP3]]|0.406|
|[[:human genes:n:narfl|NARFL]]|0.406|
|[[:human genes:h:hap1|HAP1]]|0.405|
|[[:human genes:l:lrrc56|LRRC56]]|0.405|
|[[:human genes:g:gata3|GATA3]]|0.405|
|[[:human genes:r:rfc1|RFC1]]|0.405|
|[[:human genes:w:wdr75|WDR75]]|0.404|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.404|
|[[:human genes:r:rpl26|RPL26]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.403|
|[[:human genes:c:ctr9|CTR9]]|0.403|
|[[:human genes:n:nfatc4|NFATC4]]|0.402|
|[[:human genes:r:rpl19|RPL19]]|0.402|
|[[:human genes:t:tspy2|TSPY2]]|0.402|
|[[:human genes:u:usp35|USP35]]|0.401|
|[[:human genes:i:itga2b|ITGA2B]]|0.401|
|[[:human genes:k:krt78|KRT78]]|0.401|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.4|
|[[:human genes:c:cdh24|CDH24]]|0.4|
|[[:human genes:a:acd|ACD]]|0.4|
|[[:human genes:p:psmd1|PSMD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 920
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPB1 Expression in NALM6 Cells: 7.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>