======= COPB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPB2
  * **<color #00a2e8>Official Name</color>**: COPI coat complex subunit beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9276|9276]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35606|P35606]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Coatomer WDAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI vesicle coat|
|intra-Golgi vesicle-mediated transport|
|toxin transport|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|transport vesicle|
|structural molecule activity|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|Golgi membrane|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-3.37|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.25|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-3.16|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.1|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.9|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.58|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.56|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.5|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.08|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.04|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.99|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.99|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.93|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.81|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.77|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.74|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.74|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.7|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.71|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.72|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.75|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.81|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.82|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.83|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.83|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.84|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.85|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.88|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.89|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.89|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.92|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.96|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.15|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.15|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.15|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.2|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.25|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.28|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.31|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.34|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.42|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.47|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.55|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.56|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.65|
|[[:results:exp100|NFN1 1μM R03 exp100]]|2.65|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.7|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copz1|COPZ1]]|0.593|
|[[:human genes:c:copb1|COPB1]]|0.56|
|[[:human genes:c:copg1|COPG1]]|0.551|
|[[:human genes:s:supt6h|SUPT6H]]|0.507|
|[[:human genes:p:prim1|PRIM1]]|0.498|
|[[:human genes:a:arcn1|ARCN1]]|0.497|
|[[:human genes:v:vps52|VPS52]]|0.491|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.49|
|[[:human genes:c:copa|COPA]]|0.49|
|[[:human genes:c:cbwd3|CBWD3]]|0.482|
|[[:human genes:d:dtl|DTL]]|0.474|
|[[:human genes:p:pan3|PAN3]]|0.47|
|[[:human genes:o:osbp|OSBP]]|0.468|
|[[:human genes:s:slc6a17|SLC6A17]]|0.468|
|[[:human genes:v:vps54|VPS54]]|0.463|
|[[:human genes:p:psmb2|PSMB2]]|0.463|
|[[:human genes:c:cbwd6|CBWD6]]|0.46|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.457|
|[[:human genes:c:cope|COPE]]|0.456|
|[[:human genes:a:ankle2|ANKLE2]]|0.456|
|[[:human genes:b:bysl|BYSL]]|0.456|
|[[:human genes:c:cbwd5|CBWD5]]|0.455|
|[[:human genes:m:myb|MYB]]|0.453|
|[[:human genes:c:c14orf93|C14orf93]]|0.453|
|[[:human genes:d:ddx56|DDX56]]|0.452|
|[[:human genes:s:sf3a1|SF3A1]]|0.452|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.45|
|[[:human genes:r:rrp15|RRP15]]|0.449|
|[[:human genes:v:vasn|VASN]]|0.448|
|[[:human genes:t:tceb3c|TCEB3C]]|0.445|
|[[:human genes:p:psmd11|PSMD11]]|0.445|
|[[:human genes:p:pan2|PAN2]]|0.442|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.442|
|[[:human genes:r:rpl14|RPL14]]|0.439|
|[[:human genes:p:prkcz|PRKCZ]]|0.438|
|[[:human genes:c:chd4|CHD4]]|0.437|
|[[:human genes:u:upf1|UPF1]]|0.437|
|[[:human genes:c:cdca5|CDCA5]]|0.436|
|[[:human genes:p:pole|POLE]]|0.436|
|[[:human genes:m:myo1h|MYO1H]]|0.435|
|[[:human genes:z:znf655|ZNF655]]|0.434|
|[[:human genes:s:supt5h|SUPT5H]]|0.432|
|[[:human genes:n:npipb5|NPIPB5]]|0.432|
|[[:human genes:n:nupl1|NUPL1]]|0.432|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.43|
|[[:human genes:p:pola1|POLA1]]|0.429|
|[[:human genes:s:sys1|SYS1]]|0.428|
|[[:human genes:r:rad51|RAD51]]|0.427|
|[[:human genes:c:clcn6|CLCN6]]|0.427|
|[[:human genes:w:wdr43|WDR43]]|0.426|
|[[:human genes:t:ticrr|TICRR]]|0.425|
|[[:human genes:r:rpl34|RPL34]]|0.425|
|[[:human genes:m:mt1e|MT1E]]|0.425|
|[[:human genes:o:orc1|ORC1]]|0.425|
|[[:human genes:r:rpl35|RPL35]]|0.424|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.422|
|[[:human genes:p:psmd3|PSMD3]]|0.42|
|[[:human genes:t:twistnb|TWISTNB]]|0.42|
|[[:human genes:p:pwp2|PWP2]]|0.419|
|[[:human genes:n:nol10|NOL10]]|0.416|
|[[:human genes:c:ccna2|CCNA2]]|0.416|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.412|
|[[:human genes:z:znf830|ZNF830]]|0.411|
|[[:human genes:p:polr2g|POLR2G]]|0.411|
|[[:human genes:t:tonsl|TONSL]]|0.411|
|[[:human genes:a:aamp|AAMP]]|0.411|
|[[:human genes:r:rrp7a|RRP7A]]|0.41|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.409|
|[[:human genes:g:gprin2|GPRIN2]]|0.407|
|[[:human genes:p:paf1|PAF1]]|0.407|
|[[:human genes:k:krt78|KRT78]]|0.407|
|[[:human genes:r:rad21|RAD21]]|0.403|
|[[:human genes:p:pcf11|PCF11]]|0.402|
|[[:human genes:p:pola2|POLA2]]|0.401|
|[[:human genes:h:hap1|HAP1]]|0.401|
|[[:human genes:y:ythdc1|YTHDC1]]|0.401|
|[[:human genes:o:orc6|ORC6]]|0.401|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.4|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.4|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.4|
|[[:human genes:c:casc3|CASC3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPB2 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>