======= COPS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COPS3
  * **<color #00a2e8>Official Name</color>**: COP9 signalosome subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8533|8533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNS2|Q9UNS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COPS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604665|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein deneddylation|
|nucleotide-excision repair, DNA damage recognition|
|COP9 signalosome|
|transcription-coupled nucleotide-excision repair|
|nucleotide-excision repair|
|protein modification by small protein removal|
|response to light stimulus|
|post-translational protein modification|
|in utero embryonic development|
|response to radiation|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|embryo development|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to abiotic stimulus|
|proteolysis|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.18|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 637/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|22/28|
|bone|23/26|
|breast|26/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|17/21|
|liver|15/20|
|lung|67/75|
|lymphocyte|14/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COPS3 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>