======= COQ5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ5
  * **<color #00a2e8>Official Name</color>**: coenzyme Q5, methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84274|84274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5HYK3|Q5HYK3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). {ECO:0000255|HAMAP- Rule:MF_03191}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 12|
|Methyltransf 18|
|Methyltransf 11|
|Ubie methyltran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity|
|2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|
|extrinsic component of mitochondrial inner membrane|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|quinone metabolic process|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|coenzyme biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|methylation|
|mitochondrial matrix|
|mitochondrial inner membrane|
|cofactor metabolic process|
|small molecule biosynthetic process|
|protein-containing complex|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.72|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.03|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq2|COQ2]]|0.48|
|[[:human genes:c:crls1|CRLS1]]|0.48|
|[[:human genes:m:mrps34|MRPS34]]|0.478|
|[[:human genes:c:coq4|COQ4]]|0.475|
|[[:human genes:s:sco2|SCO2]]|0.464|
|[[:human genes:s:slc25a26|SLC25A26]]|0.46|
|[[:human genes:g:gfm1|GFM1]]|0.456|
|[[:human genes:m:mrpl44|MRPL44]]|0.456|
|[[:human genes:m:mrpl15|MRPL15]]|0.456|
|[[:human genes:t:triap1|TRIAP1]]|0.456|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.455|
|[[:human genes:d:dap3|DAP3]]|0.453|
|[[:human genes:q:qrsl1|QRSL1]]|0.447|
|[[:human genes:w:wbscr16|WBSCR16]]|0.447|
|[[:human genes:r:rpusd3|RPUSD3]]|0.444|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.443|
|[[:human genes:h:higd2a|HIGD2A]]|0.442|
|[[:human genes:c:coq6|COQ6]]|0.439|
|[[:human genes:g:gfm2|GFM2]]|0.439|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.438|
|[[:human genes:m:mrps21|MRPS21]]|0.436|
|[[:human genes:m:mrpl23|MRPL23]]|0.434|
|[[:human genes:n:nars2|NARS2]]|0.433|
|[[:human genes:t:timm13|TIMM13]]|0.433|
|[[:human genes:m:mrps14|MRPS14]]|0.433|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.427|
|[[:human genes:c:coq3|COQ3]]|0.426|
|[[:human genes:m:mrps16|MRPS16]]|0.426|
|[[:human genes:m:mrpl21|MRPL21]]|0.425|
|[[:human genes:b:bcs1l|BCS1L]]|0.422|
|[[:human genes:m:mrps25|MRPS25]]|0.42|
|[[:human genes:m:mrps33|MRPS33]]|0.418|
|[[:human genes:s:selrc1|SELRC1]]|0.418|
|[[:human genes:s:sars2|SARS2]]|0.418|
|[[:human genes:c:cox6c|COX6C]]|0.417|
|[[:human genes:h:hars2|HARS2]]|0.417|
|[[:human genes:y:yars2|YARS2]]|0.416|
|[[:human genes:m:mrpl53|MRPL53]]|0.416|
|[[:human genes:c:coa6|COA6]]|0.412|
|[[:human genes:c:cox16|COX16]]|0.409|
|[[:human genes:m:mrps5|MRPS5]]|0.409|
|[[:human genes:u:uqcc2|UQCC2]]|0.404|
|[[:human genes:t:tomm22|TOMM22]]|0.402|
|[[:human genes:p:pars2|PARS2]]|0.401|
|[[:human genes:l:lars2|LARS2]]|0.401|
|[[:human genes:m:mrpl45|MRPL45]]|0.401|
|[[:human genes:p:pdss1|PDSS1]]|0.401|
|[[:human genes:p:pitrm1|PITRM1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ5 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>