======= CORO1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CORO1A
  * **<color #00a2e8>Official Name</color>**: coronin 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11151|11151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31146|P31146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CORO1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CORO1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|DUF1900|
|DUF1899|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|early endosome to recycling endosome transport|
|uropod organization|
|natural killer cell degranulation|
|negative regulation of vesicle fusion|
|myosin heavy chain binding|
|negative regulation of actin nucleation|
|nerve growth factor signaling pathway|
|immunological synapse formation|
|phagolysosome assembly|
|phosphatidylinositol 3-kinase binding|
|natural killer cell activation involved in immune response|
|vesicle-mediated transport between endosomal compartments|
|natural killer cell mediated cytotoxicity|
|phagocytic cup|
|regulation of actin nucleation|
|actin monomer binding|
|natural killer cell mediated immunity|
|neurotrophin signaling pathway|
|cellular response to interleukin-4|
|homeostasis of number of cells within a tissue|
|regulation of vesicle fusion|
|response to interleukin-4|
|T cell homeostasis|
|immunological synapse|
|leukocyte mediated cytotoxicity|
|phagosome maturation|
|positive chemotaxis|
|cellular response to nerve growth factor stimulus|
|cortical actin cytoskeleton|
|response to nerve growth factor|
|lymphocyte homeostasis|
|natural killer cell activation|
|lytic vacuole organization|
|lysosome organization|
|phagocytic vesicle|
|leukocyte homeostasis|
|cell-cell recognition|
|phagocytic vesicle membrane|
|cytoskeletal protein binding|
|regulation of release of sequestered calcium ion into cytosol|
|actin filament|
|cell killing|
|positive regulation of T cell proliferation|
|regulation of calcium ion transport into cytosol|
|lymphocyte activation involved in immune response|
|regulation of sequestering of calcium ion|
|vacuole organization|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|negative regulation of supramolecular fiber organization|
|positive regulation of leukocyte proliferation|
|negative regulation of cytoskeleton organization|
|leukocyte chemotaxis|
|negative regulation of neuron apoptotic process|
|cytosolic transport|
|regulation of calcium ion transmembrane transport|
|regulation of cell shape|
|regulation of T cell proliferation|
|regulation of actin filament polymerization|
|cell-cell junction|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cell-substrate adhesion|
|protein C-terminus binding|
|tissue homeostasis|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|actin filament binding|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of protein polymerization|
|cell recognition|
|actin filament organization|
|regulation of calcium ion transport|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|early endosome|
|regulation of actin filament organization|
|lymphocyte mediated immunity|
|actin binding|
|divalent metal ion transport|
|axon|
|regulation of leukocyte cell-cell adhesion|
|vesicle organization|
|divalent inorganic cation transport|
|regulation of neuron death|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|phagocytosis|
|regulation of cation transmembrane transport|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|positive regulation of lymphocyte activation|
|negative regulation of organelle organization|
|regulation of cellular component size|
|leukocyte migration|
|lymphocyte activation|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|leukocyte degranulation|
|regulation of anatomical structure size|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|actin filament-based process|
|protein-containing complex|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|organelle assembly|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|cation transport|
|regulation of cell migration|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|ion transport|
|RNA binding|
|response to endogenous stimulus|
|intracellular transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CORO1A Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>