======= CORO2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CORO2B
  * **<color #00a2e8>Official Name</color>**: coronin 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10391|10391]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ03|Q9UQ03]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CORO2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CORO2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605002|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the reorganization of neuronal actin structure.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|DUF1900|
|DUF1899|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|talin binding|
|regulation of glomerular filtration|
|vinculin binding|
|renal system process involved in regulation of blood volume|
|negative regulation of stress fiber assembly|
|negative regulation of actin filament bundle assembly|
|renal system process involved in regulation of systemic arterial blood pressure|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|regulation of renal system process|
|adherens junction assembly|
|cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|regulation of stress fiber assembly|
|adherens junction organization|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of systemic arterial blood pressure|
|renal system process|
|cell-matrix adhesion|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|cell junction assembly|
|regulation of blood pressure|
|cell-substrate adhesion|
|negative regulation of establishment of protein localization|
|actin filament binding|
|regulation of cell-substrate adhesion|
|cell junction organization|
|actin cytoskeleton|
|regulation of actin filament organization|
|actin binding|
|negative regulation of cell adhesion|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|focal adhesion|
|positive regulation of establishment of protein localization|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|regulation of cytoskeleton organization|
|actin filament-based process|
|regulation of system process|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|regulation of establishment of protein localization|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|regulation of protein localization|
|cytoskeleton organization|
|regulation of organelle organization|
|regulation of response to stress|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.08|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CORO2B Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>