======= COX11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX11
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase copper chaperone COX11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1353|1353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6N1|Q9Y6N1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CtaG Cox11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of glucokinase activity|
|negative regulation of hexokinase activity|
|regulation of glucokinase activity|
|regulation of hexokinase activity|
|integral component of mitochondrial inner membrane|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of carbohydrate metabolic process|
|copper ion binding|
|electron transfer activity|
|regulation of glucose metabolic process|
|regulation of cellular carbohydrate metabolic process|
|electron transport chain|
|regulation of carbohydrate metabolic process|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|protein-containing complex|
|metal ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of kinase activity|
|oxidation-reduction process|
|regulation of transferase activity|
|chemical homeostasis|
|negative regulation of molecular function|
|mitochondrion|
|regulation of phosphorylation|
|homeostatic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.49|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.7|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coa3|COA3]]|0.671|
|[[:human genes:s:selrc1|SELRC1]]|0.656|
|[[:human genes:s:sco2|SCO2]]|0.655|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.641|
|[[:human genes:n:nars2|NARS2]]|0.633|
|[[:human genes:p:pet117|PET117]]|0.627|
|[[:human genes:a:aars2|AARS2]]|0.611|
|[[:human genes:c:coa6|COA6]]|0.601|
|[[:human genes:e:ears2|EARS2]]|0.595|
|[[:human genes:l:lars2|LARS2]]|0.586|
|[[:human genes:y:yars2|YARS2]]|0.585|
|[[:human genes:t:tars2|TARS2]]|0.583|
|[[:human genes:m:mettl17|METTL17]]|0.571|
|[[:human genes:p:pet112|PET112]]|0.569|
|[[:human genes:p:pars2|PARS2]]|0.568|
|[[:human genes:c:cox16|COX16]]|0.567|
|[[:human genes:q:qrsl1|QRSL1]]|0.563|
|[[:human genes:m:mrpl21|MRPL21]]|0.562|
|[[:human genes:b:bcs1l|BCS1L]]|0.56|
|[[:human genes:m:mrps16|MRPS16]]|0.56|
|[[:human genes:f:fastkd5|FASTKD5]]|0.552|
|[[:human genes:d:dap3|DAP3]]|0.552|
|[[:human genes:r:rars2|RARS2]]|0.549|
|[[:human genes:p:polg2|POLG2]]|0.544|
|[[:human genes:f:ftsj2|FTSJ2]]|0.544|
|[[:human genes:m:mrpl23|MRPL23]]|0.539|
|[[:human genes:v:vars2|VARS2]]|0.538|
|[[:human genes:p:polg|POLG]]|0.533|
|[[:human genes:m:malsu1|MALSU1]]|0.525|
|[[:human genes:d:dars2|DARS2]]|0.522|
|[[:human genes:m:mrps6|MRPS6]]|0.522|
|[[:human genes:g:gfm2|GFM2]]|0.519|
|[[:human genes:r:rpusd4|RPUSD4]]|0.516|
|[[:human genes:m:mrps26|MRPS26]]|0.515|
|[[:human genes:w:wars2|WARS2]]|0.514|
|[[:human genes:m:mrps21|MRPS21]]|0.509|
|[[:human genes:m:mrps5|MRPS5]]|0.508|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.506|
|[[:human genes:f:fars2|FARS2]]|0.505|
|[[:human genes:g:gfm1|GFM1]]|0.498|
|[[:human genes:m:mrpl45|MRPL45]]|0.494|
|[[:human genes:n:ndufb11|NDUFB11]]|0.488|
|[[:human genes:m:mtg1|MTG1]]|0.488|
|[[:human genes:h:hars2|HARS2]]|0.488|
|[[:human genes:c:cox15|COX15]]|0.487|
|[[:human genes:m:mrps12|MRPS12]]|0.486|
|[[:human genes:m:mrps2|MRPS2]]|0.486|
|[[:human genes:m:mrps25|MRPS25]]|0.486|
|[[:human genes:m:mrpl53|MRPL53]]|0.485|
|[[:human genes:m:mtg2|MTG2]]|0.479|
|[[:human genes:m:mrps22|MRPS22]]|0.478|
|[[:human genes:g:gatc|GATC]]|0.477|
|[[:human genes:m:mrps34|MRPS34]]|0.477|
|[[:human genes:c:cox20|COX20]]|0.476|
|[[:human genes:m:mrpl47|MRPL47]]|0.474|
|[[:human genes:m:mrps24|MRPS24]]|0.474|
|[[:human genes:n:ndufb6|NDUFB6]]|0.473|
|[[:human genes:c:cars2|CARS2]]|0.472|
|[[:human genes:m:mrpl43|MRPL43]]|0.472|
|[[:human genes:c:coq2|COQ2]]|0.47|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.468|
|[[:human genes:m:mrpl11|MRPL11]]|0.467|
|[[:human genes:m:mrpl49|MRPL49]]|0.467|
|[[:human genes:c:cox7b|COX7B]]|0.466|
|[[:human genes:c:c10orf2|C10orf2]]|0.466|
|[[:human genes:m:mtpap|MTPAP]]|0.462|
|[[:human genes:m:mars2|MARS2]]|0.461|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.46|
|[[:human genes:m:mrpl20|MRPL20]]|0.46|
|[[:human genes:m:mrpl3|MRPL3]]|0.458|
|[[:human genes:m:mrps14|MRPS14]]|0.457|
|[[:human genes:c:cox6b1|COX6B1]]|0.456|
|[[:human genes:w:wbscr16|WBSCR16]]|0.455|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.455|
|[[:human genes:d:ddx28|DDX28]]|0.454|
|[[:human genes:m:mrps27|MRPS27]]|0.454|
|[[:human genes:u:uqcc1|UQCC1]]|0.454|
|[[:human genes:t:tefm|TEFM]]|0.453|
|[[:human genes:e:eral1|ERAL1]]|0.453|
|[[:human genes:c:cox17|COX17]]|0.452|
|[[:human genes:r:rbfa|RBFA]]|0.452|
|[[:human genes:m:mrpl39|MRPL39]]|0.449|
|[[:human genes:t:tfb1m|TFB1M]]|0.446|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.445|
|[[:human genes:m:mcat|MCAT]]|0.441|
|[[:human genes:m:mrps35|MRPS35]]|0.441|
|[[:human genes:p:pitrm1|PITRM1]]|0.44|
|[[:human genes:m:mrpl12|MRPL12]]|0.437|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.437|
|[[:human genes:m:mrpl44|MRPL44]]|0.434|
|[[:human genes:s:ssbp1|SSBP1]]|0.434|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.433|
|[[:human genes:m:mto1|MTO1]]|0.429|
|[[:human genes:c:cox4i1|COX4I1]]|0.429|
|[[:human genes:r:rpusd3|RPUSD3]]|0.424|
|[[:human genes:c:c12orf65|C12orf65]]|0.422|
|[[:human genes:n:nsun4|NSUN4]]|0.421|
|[[:human genes:m:mrpl2|MRPL2]]|0.421|
|[[:human genes:p:polrmt|POLRMT]]|0.421|
|[[:human genes:n:ndufa10|NDUFA10]]|0.42|
|[[:human genes:m:mrps23|MRPS23]]|0.418|
|[[:human genes:t:tomm20|TOMM20]]|0.418|
|[[:human genes:n:ndufa3|NDUFA3]]|0.417|
|[[:human genes:p:pet100|PET100]]|0.416|
|[[:human genes:m:mrps10|MRPS10]]|0.416|
|[[:human genes:c:coq4|COQ4]]|0.415|
|[[:human genes:t:tufm|TUFM]]|0.415|
|[[:human genes:m:mrp63|MRP63]]|0.415|
|[[:human genes:m:mrpl42|MRPL42]]|0.412|
|[[:human genes:i:iba57|IBA57]]|0.411|
|[[:human genes:m:mterfd1|MTERFD1]]|0.41|
|[[:human genes:s:sco1|SCO1]]|0.41|
|[[:human genes:e:ecsit|ECSIT]]|0.409|
|[[:human genes:m:mrpl4|MRPL4]]|0.409|
|[[:human genes:n:ndufs2|NDUFS2]]|0.409|
|[[:human genes:a:acad9|ACAD9]]|0.408|
|[[:human genes:m:mipep|MIPEP]]|0.407|
|[[:human genes:m:mrpl18|MRPL18]]|0.407|
|[[:human genes:c:cox19|COX19]]|0.407|
|[[:human genes:t:tmem242|TMEM242]]|0.407|
|[[:human genes:n:nubpl|NUBPL]]|0.406|
|[[:human genes:s:sars2|SARS2]]|0.404|
|[[:human genes:p:pgm3|PGM3]]|0.404|
|[[:human genes:m:mrps18a|MRPS18A]]|0.403|
|[[:human genes:c:coa5|COA5]]|0.403|
|[[:human genes:n:ndufa2|NDUFA2]]|0.403|
|[[:human genes:m:mrpl38|MRPL38]]|0.402|
|[[:human genes:c:cox7c|COX7C]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1451
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX11 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>