======= COX17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX17
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase copper chaperone COX17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10063|10063]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14061|Q14061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604813|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cytochrome-c oxidase activity|
|copper chaperone activity|
|positive regulation of electron transfer activity|
|regulation of cytochrome-c oxidase activity|
|cuprous ion binding|
|regulation of electron transfer activity|
|copper ion transport|
|mitochondrial respiratory chain complex IV assembly|
|regulation of proton transport|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|positive regulation of oxidoreductase activity|
|copper ion binding|
|mitochondrial intermembrane space|
|regulation of oxidoreductase activity|
|mitochondrial respiratory chain complex assembly|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|transition metal ion transport|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of generation of precursor metabolites and energy|
|positive regulation of transmembrane transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|regulation of ion transmembrane transport|
|heart development|
|regulation of transmembrane transport|
|metal ion transport|
|regulation of ion transport|
|brain development|
|head development|
|cation transport|
|cellular protein-containing complex assembly|
|circulatory system development|
|positive regulation of cell population proliferation|
|central nervous system development|
|positive regulation of transport|
|ion transport|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.26|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.22|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.16|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.99|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.81|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.71|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.72|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.77|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.77|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.83|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.91|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.92|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.95|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.22|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.619|
|[[:human genes:m:mrps6|MRPS6]]|0.6|
|[[:human genes:c:cox16|COX16]]|0.599|
|[[:human genes:m:mrpl23|MRPL23]]|0.591|
|[[:human genes:m:mrps21|MRPS21]]|0.59|
|[[:human genes:m:mrps16|MRPS16]]|0.58|
|[[:human genes:m:mrps5|MRPS5]]|0.573|
|[[:human genes:d:dars2|DARS2]]|0.572|
|[[:human genes:c:coa5|COA5]]|0.558|
|[[:human genes:m:mrpl47|MRPL47]]|0.553|
|[[:human genes:t:tars2|TARS2]]|0.552|
|[[:human genes:m:mrpl21|MRPL21]]|0.548|
|[[:human genes:g:gfm1|GFM1]]|0.547|
|[[:human genes:s:selrc1|SELRC1]]|0.545|
|[[:human genes:s:sars2|SARS2]]|0.544|
|[[:human genes:m:mtpap|MTPAP]]|0.544|
|[[:human genes:d:dap3|DAP3]]|0.543|
|[[:human genes:y:yars2|YARS2]]|0.541|
|[[:human genes:r:rpusd4|RPUSD4]]|0.538|
|[[:human genes:c:coa3|COA3]]|0.534|
|[[:human genes:f:fastkd5|FASTKD5]]|0.534|
|[[:human genes:m:mrps14|MRPS14]]|0.532|
|[[:human genes:b:bcs1l|BCS1L]]|0.528|
|[[:human genes:m:mrpl15|MRPL15]]|0.528|
|[[:human genes:m:mrps2|MRPS2]]|0.528|
|[[:human genes:s:sco2|SCO2]]|0.526|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.523|
|[[:human genes:m:mrps34|MRPS34]]|0.52|
|[[:human genes:m:mrpl53|MRPL53]]|0.516|
|[[:human genes:c:cox6c|COX6C]]|0.514|
|[[:human genes:w:wbscr16|WBSCR16]]|0.511|
|[[:human genes:m:mrps33|MRPS33]]|0.504|
|[[:human genes:m:mrps25|MRPS25]]|0.503|
|[[:human genes:c:coa6|COA6]]|0.503|
|[[:human genes:r:rars2|RARS2]]|0.501|
|[[:human genes:p:pars2|PARS2]]|0.5|
|[[:human genes:p:pnpt1|PNPT1]]|0.499|
|[[:human genes:c:cox7b|COX7B]]|0.499|
|[[:human genes:n:nars2|NARS2]]|0.497|
|[[:human genes:h:hars2|HARS2]]|0.495|
|[[:human genes:q:qrsl1|QRSL1]]|0.488|
|[[:human genes:e:ears2|EARS2]]|0.487|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.487|
|[[:human genes:m:mars2|MARS2]]|0.485|
|[[:human genes:m:mrps26|MRPS26]]|0.484|
|[[:human genes:t:tufm|TUFM]]|0.483|
|[[:human genes:v:vars2|VARS2]]|0.482|
|[[:human genes:c:cox15|COX15]]|0.479|
|[[:human genes:t:tomm22|TOMM22]]|0.475|
|[[:human genes:m:mrps12|MRPS12]]|0.471|
|[[:human genes:p:pdss1|PDSS1]]|0.47|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.47|
|[[:human genes:c:cox6b1|COX6B1]]|0.468|
|[[:human genes:m:mrpl18|MRPL18]]|0.466|
|[[:human genes:m:mrp63|MRP63]]|0.463|
|[[:human genes:g:gfm2|GFM2]]|0.462|
|[[:human genes:m:mrps9|MRPS9]]|0.461|
|[[:human genes:f:ftsj2|FTSJ2]]|0.459|
|[[:human genes:f:fars2|FARS2]]|0.459|
|[[:human genes:n:ndufb11|NDUFB11]]|0.459|
|[[:human genes:m:mrpl4|MRPL4]]|0.455|
|[[:human genes:a:aifm1|AIFM1]]|0.454|
|[[:human genes:m:mrps18a|MRPS18A]]|0.453|
|[[:human genes:g:gatc|GATC]]|0.453|
|[[:human genes:c:cox11|COX11]]|0.452|
|[[:human genes:l:lars2|LARS2]]|0.452|
|[[:human genes:m:mtg2|MTG2]]|0.451|
|[[:human genes:s:slc25a26|SLC25A26]]|0.446|
|[[:human genes:m:mrps24|MRPS24]]|0.445|
|[[:human genes:p:pet117|PET117]]|0.443|
|[[:human genes:r:rbfa|RBFA]]|0.442|
|[[:human genes:m:mettl17|METTL17]]|0.437|
|[[:human genes:m:mrpl34|MRPL34]]|0.437|
|[[:human genes:m:mrpl11|MRPL11]]|0.434|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.433|
|[[:human genes:t:triap1|TRIAP1]]|0.432|
|[[:human genes:l:lsm10|LSM10]]|0.432|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.431|
|[[:human genes:m:mrpl42|MRPL42]]|0.431|
|[[:human genes:u:uqcrq|UQCRQ]]|0.429|
|[[:human genes:m:mrpl3|MRPL3]]|0.429|
|[[:human genes:m:mrps11|MRPS11]]|0.428|
|[[:human genes:m:mrpl45|MRPL45]]|0.427|
|[[:human genes:a:atp5d|ATP5D]]|0.426|
|[[:human genes:c:c12orf65|C12orf65]]|0.425|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.424|
|[[:human genes:m:mrpl55|MRPL55]]|0.424|
|[[:human genes:m:mrpl52|MRPL52]]|0.423|
|[[:human genes:c:c10orf2|C10orf2]]|0.422|
|[[:human genes:p:pet100|PET100]]|0.421|
|[[:human genes:c:cycs|CYCS]]|0.42|
|[[:human genes:n:ndufa3|NDUFA3]]|0.419|
|[[:human genes:a:atxn10|ATXN10]]|0.418|
|[[:human genes:c:cox5a|COX5A]]|0.417|
|[[:human genes:t:tefm|TEFM]]|0.417|
|[[:human genes:t:tomm20|TOMM20]]|0.415|
|[[:human genes:a:atp5sl|ATP5SL]]|0.415|
|[[:human genes:m:mrpl36|MRPL36]]|0.414|
|[[:human genes:p:ppa2|PPA2]]|0.414|
|[[:human genes:e:elac2|ELAC2]]|0.412|
|[[:human genes:c:c17orf89|C17orf89]]|0.412|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.412|
|[[:human genes:c:chchd4|CHCHD4]]|0.41|
|[[:human genes:d:dhx30|DHX30]]|0.408|
|[[:human genes:t:trmt10c|TRMT10C]]|0.408|
|[[:human genes:c:chchd1|CHCHD1]]|0.407|
|[[:human genes:m:mrpl51|MRPL51]]|0.407|
|[[:human genes:m:mrpl27|MRPL27]]|0.406|
|[[:human genes:m:mrpl13|MRPL13]]|0.404|
|[[:human genes:c:cox7c|COX7C]]|0.404|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.402|
|[[:human genes:r:rpusd3|RPUSD3]]|0.401|
|[[:human genes:s:srd5a3|SRD5A3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 175/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|9/28|
|bone|9/26|
|breast|9/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|7/20|
|lung|23/75|
|lymphocyte|7/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 189
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX17 Expression in NALM6 Cells: 3.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>