======= CPEB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPEB3
  * **<color #00a2e8>Official Name</color>**: cytoplasmic polyadenylation element binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22849|22849]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NE35|Q8NE35]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPEB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPEB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610606|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'- UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cytoplasmic translational elongation|
|negative regulation of translational elongation|
|positive regulation of mRNA polyadenylation|
|negative regulation of cytoplasmic translation|
|positive regulation of mRNA 3-end processing|
|messenger ribonucleoprotein complex|
|regulation of cytoplasmic translational elongation|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|translation repressor activity, mRNA regulatory element binding|
|apical dendrite|
|3-UTR-mediated mRNA destabilization|
|CCR4-NOT complex|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of mRNA polyadenylation|
|regulation of translational elongation|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|RNA stem-loop binding|
|translation factor activity, RNA binding|
|mRNA 3-UTR AU-rich region binding|
|regulation of mRNA 3-end processing|
|regulation of cytoplasmic translation|
|mRNA destabilization|
|positive regulation of mRNA processing|
|RNA destabilization|
|long-term memory|
|positive regulation of dendritic spine development|
|positive regulation of mRNA catabolic process|
|ribosome binding|
|cellular response to amino acid stimulus|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|mRNA 3-UTR binding|
|positive regulation of mRNA metabolic process|
|response to amino acid|
|memory|
|positive regulation of translation|
|negative regulation of translation|
|regulation of mRNA processing|
|negative regulation of cellular amide metabolic process|
|regulation of dendrite development|
|positive regulation of cellular amide metabolic process|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|regulation of mRNA catabolic process|
|cellular response to acid chemical|
|postsynaptic density|
|learning or memory|
|synapse|
|positive regulation of neuron projection development|
|cognition|
|neuron projection|
|regulation of mRNA metabolic process|
|response to acid chemical|
|regulation of translation|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|dendrite|
|positive regulation of catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|behavior|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cellular amide metabolic process|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6101
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPEB3 Expression in NALM6 Cells: 3.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>