======= CPNE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPNE1
  * **<color #00a2e8>Official Name</color>**: copine 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8904|8904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99829|Q99829]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPNE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPNE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|Copine|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of NIK/NF-kappaB signaling|
|NF-kappaB binding|
|transporter activity|
|positive regulation of cytokine-mediated signaling pathway|
|negative regulation of DNA binding|
|calcium-dependent phospholipid binding|
|positive regulation of response to cytokine stimulus|
|regulation of tumor necrosis factor-mediated signaling pathway|
|azurophil granule membrane|
|phosphatidylserine binding|
|neuron projection extension|
|endopeptidase activity|
|cellular response to calcium ion|
|developmental cell growth|
|cell growth|
|regulation of NIK/NF-kappaB signaling|
|developmental growth involved in morphogenesis|
|regulation of DNA binding|
|response to calcium ion|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of protein kinase B signaling|
|negative regulation of binding|
|regulation of response to cytokine stimulus|
|cellular response to metal ion|
|glycerophospholipid biosynthetic process|
|cellular response to inorganic substance|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|nuclear membrane|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|positive regulation of neuron differentiation|
|response to metal ion|
|phospholipid metabolic process|
|regulation of binding|
|glycerolipid metabolic process|
|developmental growth|
|growth|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to inorganic substance|
|positive regulation of nervous system development|
|organophosphate biosynthetic process|
|positive regulation of cell development|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|neuron projection development|
|regulated exocytosis|
|calcium ion binding|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|organophosphate metabolic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|secretion by cell|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cell activation|
|immune effector process|
|plasma membrane bounded cell projection organization|
|secretion|
|negative regulation of molecular function|
|cell projection organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.31|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.85|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.73|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.71|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.74|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.76|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6155
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPNE1 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>