======= CRK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRK
  * **<color #00a2e8>Official Name</color>**: CRK proto-oncogene, adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1398|1398]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46108|P46108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164762|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. {ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH2|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to endothelin|
|response to cholecystokinin|
|response to endothelin|
|helper T cell diapedesis|
|cerebellar neuron development|
|protein phosphorylated amino acid binding|
|helper T cell extravasation|
|response to yeast|
|diapedesis|
|T cell extravasation|
|reelin-mediated signaling pathway|
|cellular response to insulin-like growth factor stimulus|
|regulation of Rac protein signal transduction|
|negative regulation of natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated immunity|
|cellular response to nitric oxide|
|insulin-like growth factor receptor binding|
|negative regulation of leukocyte mediated cytotoxicity|
|response to hepatocyte growth factor|
|response to nitric oxide|
|cellular response to reactive nitrogen species|
|negative regulation of cell killing|
|protein tyrosine kinase binding|
|T cell migration|
|ephrin receptor binding|
|SH2 domain binding|
|positive regulation of smooth muscle cell migration|
|positive regulation of substrate adhesion-dependent cell spreading|
|negative regulation of lymphocyte mediated immunity|
|cellular extravasation|
|phosphotyrosine residue binding|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of T cell migration|
|regulation of natural killer cell mediated immunity|
|regulation of cell adhesion mediated by integrin|
|cellular response to nerve growth factor stimulus|
|response to fungus|
|negative regulation of leukocyte mediated immunity|
|response to bronchodilator|
|response to nerve growth factor|
|regulation of substrate adhesion-dependent cell spreading|
|activation of MAPKK activity|
|SH3/SH2 adaptor activity|
|protein self-association|
|negative regulation of innate immune response|
|scaffold protein binding|
|regulation of smooth muscle cell migration|
|regulation of lymphocyte migration|
|lymphocyte migration|
|vascular endothelial growth factor receptor signaling pathway|
|negative regulation of wound healing|
|cytoskeletal protein binding|
|regulation of leukocyte mediated cytotoxicity|
|central nervous system neuron development|
|hippocampus development|
|negative regulation of response to wounding|
|ephrin receptor signaling pathway|
|negative regulation of response to biotic stimulus|
|activation of GTPase activity|
|regulation of cell killing|
|cerebellum development|
|dendrite development|
|limbic system development|
|metencephalon development|
|cerebral cortex development|
|establishment of cell polarity|
|response to hydrogen peroxide|
|neuron migration|
|negative regulation of immune effector process|
|positive regulation of cell-substrate adhesion|
|SH3 domain binding|
|cellular response to reactive oxygen species|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|regulation of wound healing|
|Fc-gamma receptor signaling pathway|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of dendrite development|
|hindbrain development|
|regulation of cell shape|
|cellular response to transforming growth factor beta stimulus|
|positive regulation of cell morphogenesis involved in differentiation|
|response to transforming growth factor beta|
|regulation of response to wounding|
|pallium development|
|central nervous system neuron differentiation|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|cell chemotaxis|
|regulation of cell-substrate adhesion|
|negative regulation of multi-organism process|
|actin cytoskeleton|
|regulation of protein binding|
|cellular response to inorganic substance|
|membrane raft|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|telencephalon development|
|positive regulation of MAP kinase activity|
|cellular response to peptide hormone stimulus|
|negative regulation of cell motility|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|cellular response to peptide|
|activation of protein kinase activity|
|phagocytosis|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|negative regulation of response to external stimulus|
|regulation of binding|
|leukocyte migration|
|response to oxidative stress|
|forebrain development|
|regulation of actin filament-based process|
|response to peptide hormone|
|positive regulation of cell adhesion|
|cellular response to drug|
|positive regulation of GTPase activity|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|regulation of immune effector process|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|response to growth factor|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|activation of immune response|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|brain development|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRK Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>