======= CRKL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRKL
  * **<color #00a2e8>Official Name</color>**: CRK like proto-oncogene, adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1399|1399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46109|P46109]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRKL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRKL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602007|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May mediate the transduction of intracellular signals.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH2|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|helper T cell diapedesis|
|pharynx development|
|endothelin receptor signaling pathway|
|extrinsic component of postsynaptic membrane|
|cerebellar neuron development|
|helper T cell extravasation|
|regulation of skeletal muscle acetylcholine-gated channel clustering|
|diapedesis|
|parathyroid gland development|
|reelin-mediated signaling pathway|
|T cell extravasation|
|B cell apoptotic process|
|positive regulation of glial cell migration|
|regulation of neuromuscular junction development|
|regulation of receptor clustering|
|regulation of postsynaptic membrane organization|
|regulation of glial cell migration|
|retinoic acid receptor signaling pathway|
|lymphocyte apoptotic process|
|leukocyte apoptotic process|
|T cell migration|
|response to interleukin-7|
|cellular response to interleukin-7|
|acetylcholine receptor signaling pathway|
|cellular response to acetylcholine|
|response to acetylcholine|
|positive regulation of substrate adhesion-dependent cell spreading|
|cellular extravasation|
|postsynaptic signal transduction|
|phosphotyrosine residue binding|
|regulation of T cell migration|
|thymus development|
|regulation of cell adhesion mediated by integrin|
|regulation of substrate adhesion-dependent cell spreading|
|activation of MAPKK activity|
|SH3/SH2 adaptor activity|
|regulation of lymphocyte migration|
|positive regulation of Ras protein signal transduction|
|cranial skeletal system development|
|lymphocyte migration|
|positive regulation of gliogenesis|
|positive regulation of small GTPase mediated signal transduction|
|outflow tract morphogenesis|
|neuromuscular junction|
|central nervous system neuron development|
|fibroblast growth factor receptor signaling pathway|
|JNK cascade|
|hippocampus development|
|signal transduction involved in cellular response to ammonium ion|
|synapse assembly|
|regulation of postsynapse organization|
|activation of GTPase activity|
|cerebellum development|
|dendrite development|
|stress-activated MAPK cascade|
|cellular response to fibroblast growth factor stimulus|
|limbic system development|
|metencephalon development|
|response to fibroblast growth factor|
|regulation of gliogenesis|
|cerebral cortex development|
|establishment of cell polarity|
|neuron migration|
|positive regulation of cell-substrate adhesion|
|endocrine system development|
|cellular response to ammonium ion|
|digestive tract development|
|male gonad development|
|development of primary male sexual characteristics|
|single fertilization|
|stress-activated protein kinase signaling cascade|
|digestive system development|
|regulation of dendrite development|
|hindbrain development|
|cellular response to transforming growth factor beta stimulus|
|positive regulation of cell morphogenesis involved in differentiation|
|activation of MAPK activity|
|male sex differentiation|
|response to transforming growth factor beta|
|intracellular receptor signaling pathway|
|fertilization|
|pallium development|
|T cell receptor signaling pathway|
|central nervous system neuron differentiation|
|response to ammonium ion|
|regulation of protein localization to membrane|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|cell chemotaxis|
|gonad development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|heart morphogenesis|
|telencephalon development|
|positive regulation of MAP kinase activity|
|sex differentiation|
|synapse organization|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|urogenital system development|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|MAPK cascade|
|leukocyte migration|
|forebrain development|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|gland development|
|positive regulation of GTPase activity|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|synaptic signaling|
|positive regulation of neurogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|spermatogenesis|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|male gamete generation|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|immune system development|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|RNA binding|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.3|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.84|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.92|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.92|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.93|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 285/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|2/28|
|bone|5/26|
|breast|11/33|
|central nervous system|23/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|10/21|
|liver|7/20|
|lung|29/75|
|lymphocyte|0/16|
|ovary|11/26|
|pancreas|19/24|
|peripheral nervous system|6/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|16/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRKL Expression in NALM6 Cells: 7.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>