======= CROCC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CROCC
  * **<color #00a2e8>Official Name</color>**: ciliary rootlet coiled-coil, rootletin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9696|9696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TZA2|Q5TZA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CROCC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CROCC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615776|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary basal body organization|
|positive regulation of protein localization to cilium|
|regulation of protein localization to cilium|
|ciliary rootlet|
|centriole-centriole cohesion|
|positive regulation of cilium assembly|
|epithelial structure maintenance|
|photoreceptor cell maintenance|
|kinesin binding|
|photoreceptor inner segment|
|positive regulation of organelle assembly|
|retina homeostasis|
|regulation of cilium assembly|
|centrosome cycle|
|microtubule organizing center organization|
|positive regulation of plasma membrane bounded cell projection assembly|
|structural constituent of cytoskeleton|
|centriole|
|tissue homeostasis|
|structural molecule activity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin cytoskeleton|
|regulation of organelle assembly|
|actin binding|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|anatomical structure homeostasis|
|establishment of organelle localization|
|cilium organization|
|positive regulation of cell projection organization|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|organelle localization|
|positive regulation of organelle organization|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.07|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.86|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.81|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.72|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.71|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.72|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.74|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.76|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.81|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.84|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.85|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.03|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.03|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.05|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pole|POLE]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1887
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CROCC Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>