======= CRP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRP
  * **<color #00a2e8>Official Name</color>**: C-reactive protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1401|1401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02741|P02741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pentaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|choline binding|
|complement component C1q binding|
|opsonization|
|virion binding|
|negative regulation of macrophage derived foam cell differentiation|
|low-density lipoprotein particle binding|
|negative regulation of lipid storage|
|positive regulation of superoxide anion generation|
|low-density lipoprotein particle receptor binding|
|regulation of superoxide anion generation|
|regulation of interleukin-8 secretion|
|regulation of macrophage derived foam cell differentiation|
|regulation of superoxide metabolic process|
|negative regulation of blood vessel diameter|
|acute-phase response|
|negative regulation of lipid localization|
|regulation of lipid storage|
|regulation of interleukin-8 production|
|acute inflammatory response|
|defense response to Gram-positive bacterium|
|positive regulation of reactive oxygen species metabolic process|
|regulation of lipid localization|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|vascular process in circulatory system|
|regulation of reactive oxygen species metabolic process|
|complement activation|
|regulation of cytokine secretion|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|phagocytosis|
|defense response to bacterium|
|humoral immune response|
|blood circulation|
|circulatory system process|
|regulation of protein secretion|
|regulation of peptide secretion|
|inflammatory response|
|regulation of anatomical structure size|
|adaptive immune response|
|activation of immune response|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|leukocyte mediated immunity|
|regulation of secretion|
|positive regulation of immune response|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of protein localization|
|identical protein binding|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|regulation of immune system process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>