======= CRTAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRTAM
  * **<color #00a2e8>Official Name</color>**: cytotoxic and regulatory T cell molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56253|56253]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95727|O95727]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRTAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRTAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|C2-set 2|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of tumor cell|
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|activated T cell proliferation|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|regulation of natural killer cell mediated immune response to tumor cell|
|response to tumor cell|
|positive regulation of immune response to tumor cell|
|positive regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|regulation of response to tumor cell|
|T cell mediated cytotoxicity|
|detection of biotic stimulus|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|T cell proliferation|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cell killing|
|leukocyte proliferation|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of leukocyte mediated immunity|
|positive regulation of cytokine secretion|
|regulation of lymphocyte mediated immunity|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|T cell activation|
|cell recognition|
|lymphocyte mediated immunity|
|positive regulation of protein secretion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of peptide secretion|
|signaling receptor binding|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|cell population proliferation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|detection of stimulus|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|leukocyte activation|
|positive regulation of transport|
|regulation of protein localization|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to biotic stimulus|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11922
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRTAM Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>