======= CRYAB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRYAB
  * **<color #00a2e8>Official Name</color>**: crystallin alpha B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1410|1410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02511|P02511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRYAB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRYAB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HSP20|
|Crystallin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of amyloid fibril formation|
|cardiac myofibril|
|regulation of amyloid fibril formation|
|tubulin complex assembly|
|actin filament bundle|
|negative regulation of protein homooligomerization|
|apoptotic process involved in morphogenesis|
|negative regulation of protein oligomerization|
|regulation of protein homooligomerization|
|structural constituent of eye lens|
|synaptic membrane|
|apoptotic process involved in development|
|M band|
|cellular response to gamma radiation|
|multicellular organism aging|
|regulation of protein oligomerization|
|microtubule polymerization or depolymerization|
|negative regulation of reactive oxygen species metabolic process|
|response to gamma radiation|
|negative regulation of intracellular transport|
|cellular response to ionizing radiation|
|lens development in camera-type eye|
|regulation of cellular response to heat|
|amyloid-beta binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|stress-activated MAPK cascade|
|response to hydrogen peroxide|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|unfolded protein binding|
|Z disc|
|perikaryon|
|response to estradiol|
|stress-activated protein kinase signaling cascade|
|dendritic spine|
|response to ionizing radiation|
|microtubule cytoskeleton|
|cellular response to radiation|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|negative regulation of cell growth|
|response to reactive oxygen species|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein folding|
|microtubule binding|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|muscle contraction|
|postsynaptic density|
|negative regulation of peptidase activity|
|protein-containing complex binding|
|aging|
|regulation of protein stability|
|axon|
|muscle organ development|
|muscle system process|
|response to antibiotic|
|camera-type eye development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|protein homooligomerization|
|response to hypoxia|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|sensory system development|
|MAPK cascade|
|response to oxygen levels|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of endopeptidase activity|
|regulation of cell growth|
|response to radiation|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|muscle structure development|
|microtubule cytoskeleton organization|
|negative regulation of transport|
|response to toxic substance|
|protein complex oligomerization|
|response to inorganic substance|
|sensory organ development|
|protein-containing complex|
|cell surface|
|regulation of growth|
|microtubule-based process|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|response to lipid|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|Golgi apparatus|
|negative regulation of cell death|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.72|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.79|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRYAB Expression in NALM6 Cells: 0.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>