======= CSF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSF3
  * **<color #00a2e8>Official Name</color>**: colony stimulating factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1440|1440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09919|P09919]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granulocyte colony-stimulating factor receptor binding|
|granulocyte differentiation|
|positive regulation of actin cytoskeleton reorganization|
|regulation of actin cytoskeleton reorganization|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of myeloid cell differentiation|
|positive regulation of actin filament polymerization|
|positive regulation of protein binding|
|positive regulation of peptidyl-serine phosphorylation|
|myeloid leukocyte differentiation|
|regulation of phosphatidylinositol 3-kinase signaling|
|response to ethanol|
|positive regulation of protein polymerization|
|regulation of peptidyl-serine phosphorylation|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of actin filament polymerization|
|cytokine activity|
|positive regulation of binding|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|positive regulation of supramolecular fiber organization|
|negative regulation of neuron death|
|cellular response to biotic stimulus|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|regulation of protein polymerization|
|regulation of myeloid cell differentiation|
|response to alcohol|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|response to antibiotic|
|regulation of neuron death|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|leukocyte differentiation|
|regulation of actin cytoskeleton organization|
|enzyme binding|
|regulation of supramolecular fiber organization|
|regulation of binding|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of DNA-binding transcription factor activity|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|response to toxic substance|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|regulation of cytoskeleton organization|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|immune system development|
|cytokine-mediated signaling pathway|
|response to bacterium|
|response to lipid|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.86|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.8|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSF3 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>