======= CSNK1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK1D
  * **<color #00a2e8>Official Name</color>**: casein kinase 1 delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1453|1453]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48730|P48730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600864|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|
|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|
|positive regulation of midbrain dopaminergic neuron differentiation|
|positive regulation of dopaminergic neuron differentiation|
|regulation of midbrain dopaminergic neuron differentiation|
|regulation of dopaminergic neuron differentiation|
|positive regulation of non-canonical Wnt signaling pathway|
|microtubule nucleation|
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|tau-protein kinase activity|
|regulation of non-canonical Wnt signaling pathway|
|protein localization to Golgi apparatus|
|microtubule polymerization|
|protein localization to microtubule cytoskeleton|
|spindle microtubule|
|protein localization to cytoskeleton|
|non-motile cilium assembly|
|protein localization to cilium|
|microtubule polymerization or depolymerization|
|circadian regulation of gene expression|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|peptidyl-threonine phosphorylation|
|protein polymerization|
|vesicle targeting|
|peptidyl-threonine modification|
|ciliary basal body-plasma membrane docking|
|vesicle budding from membrane|
|positive regulation of ubiquitin-dependent protein catabolic process|
|spindle assembly|
|positive regulation of proteasomal protein catabolic process|
|regulation of circadian rhythm|
|spindle|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|G2/M transition of mitotic cell cycle|
|Golgi organization|
|cell cycle G2/M phase transition|
|positive regulation of cellular protein catabolic process|
|circadian rhythm|
|positive regulation of canonical Wnt signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|spindle organization|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|membrane docking|
|regulation of proteasomal protein catabolic process|
|vesicle localization|
|regulation of G2/M transition of mitotic cell cycle|
|peptidyl-serine modification|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|protein kinase activity|
|regulation of cellular protein catabolic process|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|regulation of canonical Wnt signaling pathway|
|vesicle organization|
|cadherin binding|
|cilium assembly|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|establishment of organelle localization|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|cilium organization|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of nervous system development|
|positive regulation of cell development|
|organelle localization|
|mitotic cell cycle process|
|Golgi membrane|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|microtubule-based process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|Golgi apparatus|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|ATP binding|
|intracellular transport|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12627
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK1D Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>