======= CSNK2A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK2A1
  * **<color #00a2e8>Official Name</color>**: casein kinase 2 alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1457|1457]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68400|P68400]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK2A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK2A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/115440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:24962073}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|APH|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase CK2 complex|
|Sin3 complex|
|NuRD complex|
|PcG protein complex|
|phosphatidylcholine biosynthetic process|
|Hsp90 protein binding|
|negative regulation of ubiquitin-dependent protein catabolic process|
|chaperone-mediated protein folding|
|regulation of chromosome separation|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|phosphatidylcholine metabolic process|
|kinase activity|
|peptidyl-threonine phosphorylation|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cellular protein catabolic process|
|negative regulation of cysteine-type endopeptidase activity|
|peptidyl-threonine modification|
|regulation of chromosome segregation|
|protein N-terminus binding|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|macroautophagy|
|positive regulation of cell growth|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|regulation of signal transduction by p53 class mediator|
|ammonium ion metabolic process|
|peptidyl-serine modification|
|glycerophospholipid biosynthetic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|glycerolipid biosynthetic process|
|negative regulation of apoptotic signaling pathway|
|protein folding|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|phospholipid biosynthetic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|positive regulation of growth|
|process utilizing autophagic mechanism|
|autophagy|
|rhythmic process|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|regulation of growth|
|regulation of proteolysis|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of catabolic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|lipid metabolic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.71|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.67|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.17|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.98|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.95|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.81|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.8|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.74|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.71|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.76|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.86|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.87|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.9|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.9|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.92|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.07|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.11|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.15|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.22|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.35|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.39|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.57|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dek|DEK]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2524
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK2A1 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>