======= CSNK2A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK2A2
  * **<color #00a2e8>Official Name</color>**: casein kinase 2 alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1459|1459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19784|P19784]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK2A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK2A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/115442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APH|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PcG protein complex|
|liver regeneration|
|positive regulation of protein targeting to mitochondrion|
|phosphatidylcholine biosynthetic process|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|negative regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of chromosome separation|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of establishment of protein localization to mitochondrion|
|animal organ regeneration|
|phosphatidylcholine metabolic process|
|regulation of protein targeting|
|peptidyl-threonine phosphorylation|
|negative regulation of cellular protein catabolic process|
|acrosomal vesicle|
|peptidyl-threonine modification|
|regulation of chromosome segregation|
|protein N-terminus binding|
|chromatin|
|positive regulation of mitochondrion organization|
|cerebral cortex development|
|liver development|
|hepaticobiliary system development|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|regeneration|
|macroautophagy|
|pallium development|
|peptidyl-serine phosphorylation|
|regulation of mitochondrion organization|
|regulation of signal transduction by p53 class mediator|
|ammonium ion metabolic process|
|peptidyl-serine modification|
|glycerophospholipid biosynthetic process|
|positive regulation of intracellular transport|
|regulation of proteolysis involved in cellular protein catabolic process|
|glycerolipid biosynthetic process|
|negative regulation of apoptotic signaling pathway|
|regulation of intracellular protein transport|
|protein folding|
|phospholipid biosynthetic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|telencephalon development|
|autophagy|
|process utilizing autophagic mechanism|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|protein serine/threonine kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|forebrain development|
|regulation of apoptotic signaling pathway|
|gland development|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of establishment of protein localization|
|organophosphate biosynthetic process|
|regulation of cellular protein localization|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|positive regulation of organelle organization|
|gamete generation|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.77|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.71|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.76|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.87|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3402
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK2A2 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>