======= CST11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CST11
  * **<color #00a2e8>Official Name</color>**: cystatin 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=140880|140880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H112|Q9H112]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CST11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CST11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609731|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. {ECO:0000269|PubMed:12072414}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cystatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm head|
|cysteine-type endopeptidase inhibitor activity|
|androgen receptor signaling pathway|
|sperm flagellum|
|killing of cells of other organism|
|disruption of cells of other organism|
|intracellular steroid hormone receptor signaling pathway|
|defense response to Gram-negative bacterium|
|cell killing|
|steroid hormone mediated signaling pathway|
|modification of morphology or physiology of other organism|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|response to steroid hormone|
|defense response to bacterium|
|negative regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|response to bacterium|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.85|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.98|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CST11 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>