======= CST3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CST3
  * **<color #00a2e8>Official Name</color>**: cystatin C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1471|1471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01034|P01034]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CST3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CST3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604312|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cystatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of elastin catabolic process|
|negative regulation of collagen catabolic process|
|regulation of elastin catabolic process|
|negative regulation of blood vessel remodeling|
|negative regulation of extracellular matrix disassembly|
|regulation of collagen catabolic process|
|regulation of blood vessel remodeling|
|negative regulation of collagen metabolic process|
|negative regulation of extracellular matrix organization|
|peptidase inhibitor activity|
|regulation of extracellular matrix disassembly|
|negative regulation of glycoprotein metabolic process|
|negative regulation of tissue remodeling|
|cysteine-type endopeptidase inhibitor activity|
|endopeptidase inhibitor activity|
|regulation of extracellular matrix organization|
|regulation of collagen metabolic process|
|regulation of glycoprotein metabolic process|
|tertiary granule lumen|
|regulation of tissue remodeling|
|amyloid-beta binding|
|protease binding|
|ficolin-1-rich granule lumen|
|negative regulation of protein catabolic process|
|negative regulation of endopeptidase activity|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|endoplasmic reticulum lumen|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|post-translational protein modification|
|regulation of protein catabolic process|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cellular catabolic process|
|leukocyte activation|
|negative regulation of developmental process|
|Golgi apparatus|
|regulation of catabolic process|
|secretion by cell|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|defense response|
|extracellular space|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12834
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CST3 Expression in NALM6 Cells: 1.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>