======= CSTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSTB
  * **<color #00a2e8>Official Name</color>**: cystatin B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1476|1476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04080|P04080]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cystatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase inhibitor activity|
|endopeptidase inhibitor activity|
|tertiary granule lumen|
|adult locomotory behavior|
|protease binding|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|adult behavior|
|locomotory behavior|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|behavior|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|regulation of proteolysis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|nucleolus|
|leukocyte activation|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|RNA binding|
|extracellular space|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-4.47|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.86|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.81|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.61|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.96|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11773
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSTB Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>