======= CSTF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSTF2
  * **<color #00a2e8>Official Name</color>**: cleavage stimulation factor subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1478|1478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33240|P33240]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSTF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSTF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:9199325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cleavage body|
|pre-mRNA cleavage required for polyadenylation|
|mRNA cleavage involved in mRNA processing|
|tRNA splicing, via endonucleolytic cleavage and ligation|
|RNA splicing, via endonucleolytic cleavage and ligation|
|mRNA cleavage and polyadenylation specificity factor complex|
|mRNA cleavage|
|mRNA polyadenylation|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|tRNA processing|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|tRNA metabolic process|
|nuclear body|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|ncRNA processing|
|RNA splicing|
|ncRNA metabolic process|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.76|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.7|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.72|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.1|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/14|
|ovary|1/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|1/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSTF2 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>