======= CTGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCN2
  * **<color #00a2e8>Official Name</color>**: cellular communication network factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1490|1490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29279|P29279]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/121009|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGFBP|
|Cys knot|
|VWC|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to anoxia|
|positive regulation of G0 to G1 transition|
|extracellular matrix constituent secretion|
|chondrocyte proliferation|
|positive regulation of cardiac muscle contraction|
|positive regulation of striated muscle contraction|
|insulin-like growth factor binding|
|cartilage condensation|
|cell aggregation|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|fibronectin binding|
|response to mineralocorticoid|
|regulation of collagen biosynthetic process|
|positive regulation of heart contraction|
|regulation of collagen metabolic process|
|regulation of G0 to G1 transition|
|positive regulation of muscle contraction|
|regulation of chondrocyte differentiation|
|positive regulation of stress fiber assembly|
|positive regulation of actin filament bundle assembly|
|cis-Golgi network|
|positive regulation of blood circulation|
|regulation of cartilage development|
|regulation of cardiac muscle contraction|
|regulation of stress fiber assembly|
|fibroblast growth factor receptor signaling pathway|
|response to fatty acid|
|cytosolic calcium ion transport|
|regulation of actomyosin structure organization|
|regulation of striated muscle contraction|
|regulation of actin filament bundle assembly|
|integrin-mediated signaling pathway|
|cellular response to fibroblast growth factor stimulus|
|DNA biosynthetic process|
|reactive oxygen species metabolic process|
|response to amino acid|
|response to fibroblast growth factor|
|cell-matrix adhesion|
|integrin binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to estradiol|
|cell cortex|
|response to glucose|
|positive regulation of JNK cascade|
|response to hexose|
|response to monosaccharide|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of muscle contraction|
|response to corticosteroid|
|growth factor activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|lung development|
|heparin binding|
|cartilage development|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|respiratory tube development|
|transcription initiation from RNA polymerase II promoter|
|cell-substrate adhesion|
|regulation of JNK cascade|
|protein C-terminus binding|
|tissue homeostasis|
|positive regulation of peptidase activity|
|respiratory system development|
|positive regulation of supramolecular fiber organization|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|DNA-templated transcription, initiation|
|positive regulation of cytoskeleton organization|
|connective tissue development|
|extracellular matrix|
|regulation of stress-activated MAPK cascade|
|regulation of muscle system process|
|regulation of stress-activated protein kinase signaling cascade|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|regulation of heart contraction|
|calcium ion transport|
|regulation of actin filament organization|
|ossification|
|aging|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|angiogenesis|
|multicellular organismal homeostasis|
|response to steroid hormone|
|extracellular matrix organization|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|positive regulation of cell cycle|
|response to oxygen levels|
|extracellular structure organization|
|regulation of actin filament-based process|
|response to peptide hormone|
|blood vessel morphogenesis|
|epidermis development|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|regulation of peptidase activity|
|response to peptide|
|transcription by RNA polymerase II|
|blood vessel development|
|skeletal system development|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|cell population proliferation|
|response to wounding|
|regulation of system process|
|positive regulation of organelle organization|
|metal ion transport|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cation transport|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10038
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTGF Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>